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Name:

Dr.Dziedzom K. de SOUZA (PhD, BSc)

Email address:

ddesouza@noguchi.ug.edu.gh

Telephone:

+233-302-501178

Fax:

+233-302-502182

Department:

Parasitology

Biography

Dziedzom De Souza is a young research fellow in the Parasitology Department of the Noguchi Memorial Institute for Medical Research, University of Ghana. He obtained his Bachelor of Science in Zoology (Second Class Upper) at the University of Ghana in 2003 and earned a PhD in Biological Sciences at the Kwame Nkrumah University of Science and Technology, Ghana in 2011. His interests are in the molecular biology of disease vectors and parasites, medical entomology, climate change and geographic information systems (GIS).Currently, his main research focus involves assessing the transmission of Lymphatic Filariasis, using molecular xenomonitoring methods. He has led entomological investigations, and has been involved in providing training, diagnostics, monitoring and evaluation support to other project countries in Africa including, Liberia and Sierra Leone, Guinea and Ethiopia. His additional research interests include Buruli Ulcer transmission and diagnosis. He has received many local and international competitive awards for young scientists. He is fluent in English and French and has published many articles in international peer reviewed journals.

Administrative Role

Quality Manager (Parasitology Department)

Research Interests

Molecular Biology of Disease Vectors and Parasites

Lymphatic Filariasis and other Neglected Tropical Diseases

Projects:

NMIMR Projects

  • Improving xenomonitoring for assessing Anopheles-transmitted filariasis after several rounds of MDA to interrupt Lymphatic Filariasis transmission in Africa. (Duration: 2016-2018: - 30 months. Role: Supervisor. Sponsor: WellcomeTrust Master’s Training Fellowship - 200076/Z/15/Z, to Millicent Opoku. Amount: GBP:85,690.00)
  • Operational research to determine the reasons for the persistence of LF transmission in two hot spot districts in Ghana and the development and testing of alternative strategies to accelerate elimination (Duration: 2015-2017 – 24 months. Role: Principal Investigator. Sponsors: DFID through the Centre for Neglected Tropical Diseases and Sightsavers. Amount: GBP 39, 296.00).
  • Evaluating the impact of insecticide resistance on the adaptation of Anopheles gambiae to breeding in polluted water bodies (Duration: 2015-2016 – 18 months. Role: Principal Investigator. Sponsor: The World Academy of Science –TWAS. Amount: US $ 15,000.00).

 

Other Projects; None NMIMR projects

  • Helminth control via mass drug administration: simulating the development and spread of parasite resistance against the drugs used. A collaborative study submitted with Erasmus MC, Rotterdam-Netherlands. (Duration: 2015-2016 – 18 months. Role: Co-Investigator. Sponsor: Tropical Diseases Research. Amount: US $ 128,000.00).

Publications:

NMIMR Publications

  1. Kawada H, Higa Y, Futami K, Muranami Y, Kawashima E, Osei JHN, Dadzie S, Sakyi KY, de Souza DK, Appawu M, Ohta N, Suzuki T, Minakawa N (2016). Discovery of the Point Mutation in the Voltage-Gated Sodium Channel (kdr) from African Aedesaegypti (L.) Populations Collected in Ghana and Potential Phylogenetic Reasons for Gene Introgression. PLoSNegl Trop Dis 10(6): e0004780. Doi:10.1371/journal.pntd.0004780.
  2. de Souza DK, Yirenkyi E, Otchere J, Biritwum NK, Ameme DK, Sackey S, Ahorlu C, Wilson MD (2016). Assessing Lymphatic Filariasis Data Quality in Endemic Communities in Ghana, Using the Neglected Tropical Diseases Data Quality Assessment Tool for Preventive Chemotherapy. PLoSNegl Trop Dis 10(3): e0004590. doi:10.1371/journal.pntd.0004590.
  3. Kouassi BL, de Souza DK, Goepogui A, Balde SM, Diakite L, Sagno A, Djamey, IG, Chammartin F, Vonatsou P, Bockarie MJ, Utzinger J and BG Koudou(2016). Low prevalence of Plasmodium and absence of malaria transmission in Conakry, Guinea: prospects for elimination. Malaria Journal. 15:175. DOI 10.1186/s12936-016-1230-9
  4. de Souza DK, Alidu SS, Akorli J, Suzuki T (2016). Evaluating triethylamine in the anaesthesia of Anopheles gambiae mosquitoes African Entomology. 24(1): 236-240. DOI: http://dx.doi.org/10.4001/003.024.0236
  5. Okorie NP, de Souza DK (2016). Prospects, drawbacks and future needs of xenomonitoring for the endpoint evaluation of lymphatic filariasis elimination programs in Africa. Trans R Soc Trop Med Hyg. 110(2):90-97.
  6. de Souza DK, Ansumana R, Sessay S, Rebollo MP, Koroma J, Koudou B, Boakye DA, Bockarie MJ (2015). The impact of residual infections on Anopheles-transmitted Wuchereria bancrofti after multiple rounds of mass drug administration. Parasites and Vectors. 8:488.
  7. Kouassi BL, de Souza DK, Goepogui A, Narh CA, King SA, Mamadou BS, Dadzie S, Boakye DA, Utzinger J, Bockarie M, Koudou BG (2015). Assessing the presence of Wuchereria bancrofti in vector and human populations from urban communities in Conakry, Guinea. Parasites and Vectors. 8:492.
  8. Owusu IO, de Souza DK, Anto F, Wilson MD, Boakye DA, Bockarie MJ, Gyapong JO. (2015). Evaluation of human and mosquito based diagnostic tools for defining endpoints for elimination of Anopheles transmitted lymphatic filariasis in Ghana. Trans R Soc Trop Med Hyg. 109: 628–635.
  9. Narh CA, Mosi L, Quaye C, Dassi C, Konan DO, Tay SC, de Souza DK, Boakye DA, Bonfoh B. (2015). Source tracking Mycobacterium ulcerans infections in the Ashanti region, Ghana. PLoSNegl Trop Dis. 9(1):e0003437. doi:10.1371/journal.pntd.0003437.
  10. Agyapong J, Chabi J, Ablorde A, Kartey WD, Osei JH, de Souza DK, Dadzie S, Boakye DA, Ohta N, Hadi MP, Suzuki T. (2014). OvipositionalBehavior of Anopheles gambiae Mosquitoes. Trop Med Health. 42(4):187-90. doi: 10.2149/tmh.2014-13.
  11. de Souza DK, Osei-Poku J, Blum J, Baidoo H, Brown CA, Lawson BW, Wilson MD, Bockarie MJ, Boakye DA (2014). The epidemiology of lymphatic filariasis in Ghana, explained by the possible existence of two strains of Wuchereria bancrofti. Pan Afr Med J. 17:133. doi: 10.11604/pamj.2014.17.133.3370.
  12. Narh CA, Mosi L, Quaye C, Tay SC, Bonfoh B, de Souza DK (2014). Genotyping Tools for Mycobacterium ulcerans-Drawbacks and Future Prospects. Mycobact Dis. 5;4(2):1000149.
  13.  Dome M, Ansumana R, Covington AL, Rebollo MP, Sesay S, Jacobsen KH, de Souza DK, Koudou BG, Michael E, Bockarie MJ (2014) Lymphedema in a 7-year-old boy infected with Wuchereria bancrofti in Sierra Leone: a case report. Acta Trop. 134:13-6. doi: 10.1016/j.actatropica.2014.02.007.
  14. de Souza DK. (2014). Mitigating the spread of antimalarial drug resistance and sustaining the achievements in malaria-eliminating countries.Malaria Chemotherapy, Control and Elimination. 3:1. http://dx.doi.org/10.4172/2090-2778.1000115
  15. Obeng B, Amoah A, Larbi I, de Souza D, Uh H-W, Fernandez-Rivas M, Van Ree R, Rodrigues L, Boakye D, Yazdanbakhsh M, Hartgers F. (2014) Schistosome infection is negatively associated with mite atopy, but not wheeze and asthma in Ghanaian Schoolchildren. Clinical & Experimental Allergy. 44(7): 965-75. doi: 10.1111/cea.12307.
  16. de Souza DK, Sesay S, Moore MG, Ansumana R, Narh CA, Kollie K, Rebollo MP, Koudou BG, Koroma JB, Bolay FK, Boakye DA, Bockarie MJ. (2014)No evidence for lymphatic filariasis transmission in big cities affected by conflict related rural-urban migration in Sierra Leone and Liberia. PLoSNegl Trop Dis. 8(2):e2700. doi: 10.1371/journal.pntd.0002700.
  17. Duah NO, Matrevi SA, de Souza DK, Binnah DD, Tamakloe MM, Opoku VS, Onwona CO, Narh CA, Quashie NB, Abuaku B, Duplessis C, Kronmann KC, Koram KA. (2013). Increased pfmdr1 gene copy number and the decline in pfcrt and pfmdr1 resistance alleles in Ghanaian Plasmodium falciparum isolates after the change of anti-malarial drug treatment policy. Malar J. 12:377. doi: 10.1186/1475-2875-12-377.
  18. de Souza DK, Koudou BG, Bolay FK, Boakye DA, Bockarie MJ. (2013). Filling the gap 115 years after Ronald Ross: the distribution of the Anopheles coluzzii and Anopheles gambiaes.s from Freetown and Monrovia, West Africa. PLoS One. 8(5):e64939. doi: 10.1371/journal.pone.0064939.
  19. de Souza DK, Brown CA, Ahorlu CK, Suzuki T. (2013). Understanding the requirements and factors necessary for the acceptance of genetically modified mosquitoes as a potential malaria control tool in Ghana. Asia Pacific Journal of Molecular Biology & Biotechnology. 21 (3): 76-88.
  20. de Souza DK, Dadzie S, Osei KHN, Boakye DA, Suzuki T. (2012) Shifting the focus from open release of genetically modified mosquitoes, to controlled individualized treatment for infectious diseases. Asia Pacific Journal of Molecular Biology & Biotechnology. 20(4):  117-118.
  21. de Souza DK, Koudou B, Kelly-Hope LA, Wilson MD, Bockarie MJ, Boakye DA. (2012). Diversity and transmission competence in lymphatic filariasis vectors in West Africa, and the implications for accelerated elimination of Anopheles-transmitted filariasis. Parasit Vectors. 5:259. doi: 10.1186/1756-3305-5-259.
  22. de Souza DK, Quaye C, Mosi L, Addo P, Boakye DA. (2012). A quick and cost effective method for the diagnosis of Mycobacterium ulcerans infection. BMC Infect Dis. 12:8. doi: 10.1186/1471-2334-12-8.
  23. Brijnath B, Ansariadi, de Souza DK. (2012). Four ways geographic information systems can help to enhance health service planning and delivery for infectious diseases in low-income countries. J Health Care Poor Underserved. 23(4):1410-20. doi: 10.1353/hpu.2012.0146.
  24. Alam MT, de Souza DK, Vinayak S, Griffing SM, Poe AC, Duah NO, Ghansah A, Asamoa K, Slutsker L, Wilson MD, Barnwell JW, Udhayakumar V, Koram KA. (2011). Selective sweeps and genetic lineages of Plasmodium falciparum drug -resistant alleles in Ghana. J Infect Dis. 203(2):220-7. doi: 10.1093/infdis/jiq038.
  25. de Souza D, Kelly-Hope L, Lawson B, Wilson M, Boakye D. (2010). Environmental factors associated with the distribution of Anopheles gambiaes.s in Ghana; an important vector of lymphatic filariasis and malaria. PLoS One. 5(3):e9927. doi: 10.1371/journal.pone.0009927.
  26. Kok M, de Souza DK. (2010). Young Voices demand health research goals. Lancet. 375(9724):1416-7. doi: 10.1016/S0140-6736(10)60584-3.
  27. de Souza DK. (2010) Diversity in disease vectors and pathogens: a climate change perspective. Biodiversity. 11(3&4): 63-64.
  28. de Souza DK. (2009). Evidence-Based Approach to Decision Making: The Inclusion of GIS as Part of Ghana’s Health Information Systems. Ghana Medical Journal. 43(1): 1-6.
  29. Addo P, Quartey M, Abbas M, Adu-Addai B, Owusu E, Okang I, Dodoo A, de Souza D, Ankrah NA, Ofori-Adjei D. In-Vitro Susceptibility of Mycobacterium ulceransto Herbal Preparations. The Internet Journal of Tropical Medicine. 2008. Volume 4 Number 2.

 

Book Chapters

  1. Boakye DA, de Souza DK, Bockarie MJ. (2016). Alternative Interventions against Neglected Tropical Diseases in Sub-Saharan Africa: Vector Control. In: Neglected Tropical Diseases - Sub-Saharan Africa, Edition: 1st, Editors: Gyapong J, Boatin B, pp.268-379. ISBN 978-3-319-25471-5. Springer International Publishing - Switzerland.
  2. Wilson MD, de Souza DK, Ayi I. (2016). Soil Transmitted Helminthiasis. In: Neglected Tropical Diseases - Sub-Saharan Africa, Edition: 1st, Editors: Gyapong J, Boatin B, pp.290-311. ISBN 978-3-319-25471-5. Springer International Publishing - Switzerland.
  3. de Souza DK, Okorie PN, Adeogun AO, Elaagip AH. (2015). Disease control using GMVs: where do we stand in Africa after nearly half a century? In: Biosafety for human health and the environment in the context of the potential use of genetically modified mosquitoes (GMMs). World Health Organization. Pp 242. ISBN978 92 4 154927 1.
  4. de Souza DK, Boakye DA, Wilson MD. (2014). Towards unravelling the complexities of filarial diseases transmission and research for control in Ghana. In Towards Effective Disease Control in Ghana: Research and Policy Implications. Ahorlu CSK, Bosompem KM, Koram KA, Wilson MD, Yeboah-Manu D (Eds). University of Ghana, Accra-Ghana.
  5. de Souza DK, Owusu PN, Wilson MD. (2012). Impact of Climate Change on the Geographic Scope of Diseases. In Human and Social Dimensions of Climate Change, NetraChhetri (Ed.), ISBN: 978-953-51-0847-4, InTech, Available from: http://www.intechopen.com/books/human-and-social-dimensions-of-climate-change/impact-of-climate-change-on-the-geographic-scope-of-diseases.

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P.O. Box LG 581
Legon, Accra

+233 030 2501178/79

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