Parasitology

Dr. Anita Ghansah

Dr. Anita Ghansah

Parasitology Department

Name: Anita Ghansah (PhD)

Research Area Strengths: eg.  Genomics/Genetic Epidemiology of Malaria and other infectious diseases, Genomics and Public health

Email(s): aghansah@noguchi.ug.edu.gh

Research Group(s):

Plasmodium Diversity Network Africa (PDNA)

Community Engagement in Biobanking and Genomics (CeBioGEN)

Malaria Group

 

Ongoing Research:

 

Title: Developing Best Practices of Community Engagement for Genomics and Biobanking in Africa - CEBioGEN

Description: This study will investigate the role of community engagement in genomic research and biobanking in sub- Saharan Africa through collaborative research projects across six African countries: Ghana, Nigeria, South Africa, Tanzania and Kenya

Funding Agency: (NHGRI) 1U54HG010275-01


Date: 2018-2023

Total costs:  $1,695,505.00

Role:  PI – in charge of the overall running of the project

 

 

Title: Impacts of Environment, Host Genetics and Antigen Diversity on Malaria Vaccine Efficacy

Description: Assessing the vaccine efficacy by considering host, parasite and environmental factors at play

Funding Agency: (NIAID) 1U41HG006941-01

Date: 2018-2023

Total costs:  $3,632,091.00

Role:  Co-investigator (Sub-award PI for Noguchi Memorial Institute)  - in charge of parasite genetics studies  

 

Title: Functional Immunogenetics of Malaria

Description: Elucidating the immune-genetic predisposition to malaria

Funding Agency: (DANIDA) 14-PO1-GHA

Date: 2015-2020

Total costs: DKK 10,000,000.00

Role:  Co-applicant involved in parasite genetics studies

 

Title: Developing Excellence in Leadership and Genetic Training for Malaria Elimination in sub-Saharan Africa (DELGEME)

Description: Making genetics/genomics relevant in malaria control in Africa

Funding Agency: (Wellcome Trust) 107740/Z/15/Z

Date: 2016-2021

Total costs: GBP 5,523,781

Role:  Co-Applicant  (sub-ward PI) in charge of research management and environment hub

 

Title: Developing Excellence in Leadership and Genetic Training for Malaria Elimination in sub-Saharan Africa (DELGEME)- Aspiring leadership fellowship

Description: Training in malaria Research Leadership

Funding Agency: (Wellcome Trust) 107740/Z/15/Z

Date: 2018-2020

Total costs: GBP 30,000

Role:  Aspiring leader (PI)

 

Title: WACCIP-Wellcome Trust DELTAS Programme

Description: Training in human genetics/genomics

Funding Agency: (Wellcome Trust) 107755Z/15/Z

Date: 2016-2021

Total costs: $7,185,855

Role:  Co-Applicant, involved in human genetics training

 

Completed Research

 

Title: Impact of Distinct Eco-epidemiology on Malaria Drug Resistance in Ghana

Description: Elucidating the effect of clonal diversity on the anti-malarial drug resistance in different

ecological zones of Ghana

Funding Agency: NIAID R01AI099527

Date: 2013-2018

Total costs: $606,805

Role: PI- in charge of the overall running of the project

 

Title: A Sustainable African Bioinformatics Network for H3Africa (H3ABioNet)

Description: A Node established for basic Bioinformatics training in Ghana as part of the mother human

Hereditary and Health Africa’s (H3Africa) Bioinformatics hub (H3ABioNet)

Funding Agency: NIAID 1U41HG006941

Date: 2013-2017

Total costs: $5,000,000.00

Role: Co Principal Investigator – in charge of training

 

Title: Impact of Seasonality and vector control on population structure of P. falciparum

Description: The effect of seasonal changes and IRS on P. falciparum population structure

Funding Agency: FIC-EEID, R01-TW009670

Date: 2013-2016

Total costs:

Role: Co-investigator-responsible for parasite diversity study

 

Title: Exploring Plasmodium falciparum genome to understand the genetic diversity, emergence of drug

resistance and vaccine efficacy 

Description: The use of genomics tools to understand genetic diversity, emergence of

drug resistance and vaccine efficacy in Ghana

Funding Agency: MRC-Centre for Genomics and Global Health-Centenary Fellowship

Date: 2013-2014

Total costs: GBP 30,000

Role: PI – fellow, in charge of running the grant

 

 

 

 

 

 

 

Affiliated Departments/Institutions:

Department of Parasitology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana

Biochemistry Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana

West African Centre for Cell Biology of Infectious Pathogen (WACCIBIP), Biochemistry Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana

Harvard School of Public Health Boston, MA, USA

University of Massachusetts Medical School, MA, USA

Professional Organizations:

Member: American Society of Human Genetics

Member: American Society of Tropical Hygiene and Medicine

Member: Ghana Society for Human Genetics

Member: Plasmodium Diversity Network of Africa

 

Research Interests:

My research focuses on how parasite genetic diversity influences the epidemiology and pathogenicity of malaria and its implication on therapeutic and vaccination strategies as well as malaria vector control strategies. In addition I have a keen interest in using population genetics strategies to identify genetic loci that contribute to drug resistance in P. falciparum and the development of genomic tools to characterize P. falciparum diversity and drug resistance in the population. I am a member of the Plasmodium diversity Network Africa (PDNA), a consortium that makes use of the huge genomics data available to understand malaria parasite diversity and its effects on important phenotypes such as drug resistant parasite for malaria control. I have also been involved in Bioinformatics, genetics training in Ghana. I collaborate with the Bailey group of Brown University, USA on developing innovative tools for monitoring malaria drug resistance, on malaria vaccine efficacy studies that target parasite population dynamics, human genetics and environment impact. I am also interested in engaging/educating the research community in genomics, ultimately for improving public health. I also apply my experience in genomics in other infectious diseases and non-communicable diseases.

 

 

 

Current Research Supervision:

PhDs

Name of Student: Benedicta Ayeidu Mensah

Institution: University of Ghana, School of Public Health

Role: Co-Supervisor

Status: 2014 – 2018

 

MPhils

Name of Student: Barbara Mensah

Institution: University of Ghana, Department of Biochemistry Cell and Molecular Biology

Role: Main Supervisor

Date : 2017 – 2019

 

Name of Student: Dr. Jonathan Kpakpa

Institution: University of Ghana, Department of Biochemistry Cell and Molecular Biology

Role: Main Supervisor

Date : 2018 – 2020

Name of Student: Elikplim Amegashie

Institution: Jomo Kenyatta University of of Agriculture and Technology, Nairobi-Kenya

Role: Main Supervisor

Date : 2017 – 2019

 

Name of Student: Francis Agama

Institution: University of Cape-Town

Role: Co-Supervisor

Date : 2018 – 2020

Keywords

Malaria

Drug resistance

Parasite diversity

Genomics

Key/Notable Publications (max 10)

  1. Aydemir O, Janko M, Hathaway NJ, Verity R, Mwandagalirwa MK, Tshefu AK, Tessema SK, Marsh PW, Tran A, Reimonn T, Ghani AC, Ghansah A, Juliano JJ, Greenhouse BR, Emch M, Meshnick SR, Bailey JA.  Drug Resistance and Population Structure of Plasmodium falciparum Across the Democratic Republic of Congo using high-throughput Molecular Inversion Probes.J Infect Dis. 2018 Apr 28. doi: 10.1093/infdis/jiy223.
  2. Abuaku BK, Mensah BA, Ofori MF, Myers-Hansen J, Derkyi-Kwarteng AN, Essilfie F, Dokurugu M, Amoakoh E, Koram KA, Ghansah A.Efficacy of Artesunate/Amodiaquine in the Treatment of Uncomplicated Malaria among Children in Ghana.Am J Trop Med Hyg. 2017 Sep;97(3):690-695. doi: 10.4269/ajtmh.15-0826.
  3. Kamau E, Campino S, Amenga-Etego L, Drury E, Ishengoma D, Johnson K, Mumba D, Kekre M, Yavo W, Mead D, Bouyou-Akotet M, Apinjoh T, Golassa L, Randrianarivelojosia M, Andagalu B, Maiga-Ascofare O, Amambua-Ngwa A, Tindana P, Ghansah A, MacInnis B, Kwiatkowski D, Djimde AA. K13-propeller polymorphisms in Plasmodium falciparum parasites from sub-Saharan Africa.J Infect Dis. 2015 Apr 15;211(8):1352-5. doi: 10.1093/infdis/jiu608. Epub 2014 Nov 2. Erratum in: J Infect Dis. 2016 Jan 15;213(2):327.
  4. Blay EA, Ghansah A, Otchere J, Koku R, Kwofie KD, Bimi L, Takashi S, Ohta N, Ayi I. Congenital toxoplasmosis and pregnancy malaria detection post-partum: Effective diagnosis and its implication for efficient management of congenital infection. Parasitol Int. 2015 Dec;64(6):603-8. doi: 10.1016/j.parint.2015.08.004
  5. Ghansah A, Amenga-Etego L, Amambua-Ngwa A, Andagalu B, Apinjoh T, Bouyou-Akotet M, Cornelius V, Golassa L, Andrianaranjaka VH, Ishengoma D, Johnson K, Kamau E, Maïga-Ascofaré O, Mumba D, Tindana P, Tshefu-Kitoto A, Randrianarivelojosia M, William Y, Kwiatkowski DP, Djimde AA. Monitoring parasite diversity for malaria elimination in sub-Saharan Africa. 2014 Sep 12;345(6202):1297-8. doi: 10.1126/science.1259423. 
  6. Brown C., Awisi B., Asmah H., Dzudzor B., Ghansah A., (2013). Association between Haptoglobin Genotype Polymorphism and Type Two (2) Diabetes in Accra, Ghana. J. of Biomed. Lif. Sci. 1: 4:103-109.
  7. Ghansah A., Rockett K.A., Clark T.G., Wilson M.D., Koram K.A., Oduro A.R., Amenga-Etego L., Anyorigiya T., Hodgson A., Milligan P., Rogers W.O., Kwiatkowski D.P., (2012).  Haplotype analyses of haemoglobin C and haemoglobin S and the dynamics of the evolutionary response to malaria in Kassena-Nankana District of Ghana. PLoS One. 7(4):e34565
  8. Alam M.T., de Souza D.K., Vinayak S., Griffing S.M., Poe A.C., Duah N.O., Ghansah A., Asamoa K., Slutsker L., Wilson M.D., Barnwell J.W., Udhayakumar V., Koram K.A., (2009). Selective sweeps and genetic lineages of Plasmodium falciparum drug resistant alleles in Ghana. Infect. Dis. 15;203(2):220-7
  9. Fry A.E., Ghansah A., Small K.S., Palma A., Auburn S., Diakite M., Green A., Campino S., Teo Y.Y., Clark T.G., Jeffreys A.E., Wilson J., Jallow M., Sisay-Joof F., Pinder M., Griffiths M.J, Peshu N., Williams T.N., Newton C.R., Marsh K., Molyneux M.E., Taylor T.E., Koram K.A., Oduro A.R., Rogers W.O., Rockett K.A., Sabeti P.C., Kwiatkowski D.P., (2009) Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes, Mol. Genet. 15;18(14):2683-92.
  10. Duah NO, Wilson MD, Ghansah A, Abuaku B, Edoh D, Quashie NB, Koram KA. Mutations in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance genes, and treatment outcomes in Ghanaian children with uncomplicated malaria. J Trop Pediatr. 2007 Feb;53(1):27-31. Epub 2006 Dec 10. PubMed PMID: 17158810

 

 

1U54HG010275-01 2018-2023
NHGRI
Title: Community Engagement in Biobanking and Genomics (CEBioGen)
This study will investigate the role of community engagement in genomic research and biobanking in sub- Saharan Africa through collaborative research projects across six African countries: Ghana, Nigeria, South Africa, The Gambia, Tanzania and Kenya.
Role: PI

 

The Noguchi Memorial Institute for Medical Research (NMIMR), set up in 1979 as a semi autonomous institute of the University, is the leading biomedical research facility in Ghana.

© 2017 NMIMR

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