Professor (Mrs). Regina Appiah-Opong
The Management and staff of the Noguchi Memorial Institute for Medical Research (NMIMR) wish to congratulate Professor (Mrs.) Regina Appiah-Opong on her new appointment as an Associate Professor of toxicology in the Institute.
Professor Appiah-Opong has devoted much of her working life to biomedical research, mostly at NMIMR. She is a Toxicologist at the Department of Clinical Pathology, Head of the Department and until her promotion, a Senior Research fellow. Her PhD studies were focused on pharmacokinetic drug interactions mediated by cytochrome P450 and glutathione s-transferases drug metabolizing enzymes.
Her research interests include Toxicology/Pharmacology, Drug discovery – Anticancer, antimalarial, Drug-drug/drug-herb/drug-food interactions and Environmental contaminants – Heavy metals, aflatoxins
In 2001, she undertook further training in molecular biology techniques at the National Institute for Infectious Diseases (NIID), Tokyo, Japan and during this time contributed significantly to the construction of a DNA cassette vector that was useful for drug susceptibility testing of anti-HIV drugs.
Professor Appiah-Opong is also a part-time lecturer at the Department of Biochemistry, Cell and Molecular Biology, University of Ghana and the Principal Investigator on the University’s Research grant funded project that is conducting onshore assessment of the Jubilee oil field in the Western region of Ghana. She has been involved in projects in the area of drug discovery, evaluating the efficacy and safety of drug candidates and medicinal plants and environmental contaminants, particularly heavy metals and aflatoxins. She has been Principal investigator or co-investigator for several projects and has other funded studies currently ongoing.
Professor Appiah-Opong is collaborating with University of Washington, Bothell (where she is also an adjunct lecturer), in research on genes of cytochrome P450 drug metabolising enzymes to identify differences in SNPs between Caucasian and African ethnicities, particularly Ghanaians. The result of this study may provide a foundation for altering approaches to drug approval in Ghana and other regions of the world. She was a collaborator on the JICA/JST/Nagasaki International University/Centre for Scientific Research into Plant Medicine/NMIMR research project that investigated anti-HIV and anti-trypanosomiasis compounds in Ghanaian medicinal plants. She is also collaborating with the Pharmacology Department of Yale University Medical School on chemical and biological fingerprinting of some Ghanaian medicinal plants. She is a member of a multidisciplinary team that is investigating the efficacy of Ghanaian medicinal plants used by Traditional Medicine Practitioners to manage cancer. Currently, she is collaborating with Department of Chemistry to study the antitumor, anticancer and monoamine oxidase inhibitory potentials of isoflavones from the Millettia thonningii plants and their synthetic derivatives.
She has supervised research projects of Postdoctoral fellows (5), PhD (1), MPhil (23) and BSc (33) students in the University of Ghana and other Universities. She has also published extensively in her field of study.
The staff of NMIMR applauds you on this remarkable achievement and wishes you well in academia and all that you do.