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The next Noguchi Memorial Institute for Medical Research (NMIMR) Institutional Seminar is scheduled for tomorrow, the 6th of December, 2016.
Venue: NMIMR Conference Room

Time: 3.00pm

Presenter: Dr Arthur Baca, A Visiting Scientist to the Departments of Animal Experimentation and Bacteriology

Title of presentation: Gallium targets microbial and mycobacterial iron-uptake mechanisms. A potential treatment for Buruli Ulcer

Gallium has been used in medicine as both a diagnostic (imaging) and as a chemotherapeutic agent.  Gallium acts pharmacologically as a competitive inhibitor to iron dependent enzymes.  Living cells incorporate Ga(III) and replace Fe(III) within target proteins, disturbing essential iron metabolism. The activity of gallium mostly relies on its ability to replace iron in redox enzymes such as ribonucleotide reductase which is essential for DNA synthesis, thus impairing a cell’s function and ultimately hampering cell growth. Cancer cells and bacteria are preferential gallium targets due to their active metabolism and fast growth.  The antiproliferative effects of gallium therapy have been observed in infectious disease models (virus, bacteria, mycobacteria, parasites) and in cancer patients (rapidly growing cancer cells).  Several research groups continue to explore gallium therapy as a potential antibiotic using in vitro and animal models of infection, having tested several bacterial pathogens including intracellular bacteria.  Gallium maltolate is a new formulation of gallium that has completed phase I clinical trials in the United States and has a superior safety profile compared to the FDA-approved gallium nitrate formulation.  Based on previous data demonstrating inhibitory effects of gallium on other Mycobacterial species in a variety of in vitro and in vivo models, it is hypothesized that topical gallium maltolate could potentially serve as a safe and convenient treatment for early stage Mycobacterium ulcerans infection.  

All are encouraged to attend this seminar and on time

Thank you

Dr. William Anyan and Dr. Mrs Nancy Quashie

Seminar Coordinators

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