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Name:

Dr. Samuel Adjei , PhD

Email address:

sadjei@noguchi.ug.edu.gh

Telephone:

+233-302-501178/9ext 265

Department:

Animal Experimentation

Biography

Dr. Samuel Adjei earned BSc. (Hons) in Biological Sciences in 1992 from the Kwame Nkrumah University of Science and Technology (KNUST). In 2002, he proceeded to undertake further studies in Nagoya University, Japan where he obtained MSc. and PhD degrees in Applied Molecular Bioscience (Animal Genetics) in 2004 and 2007, respectively.

 In 2008 he became a Research Fellow in the Department of Animal Experimentation. Prior to this, he worked as a Research Assistant and assisted in the establishment of well-defined laboratory animals for biomedical research and the development of the grasscutter as a model animal for buruli ulcer research. He has taught Biology at the Advanced and Senior High School Levels for several years and is also a Part-time lecturer in Principles of Genetics (Level 300) and Advanced Genetics (Level 400)in the Department of Animal Biology and Conservation Science, School of Biological Sciences, College of Basic and Applied Sciences, University of Ghana. His specialty training encompasses Laboratory Animal Science (Breeding and quality assurance), Avian influenza molecular diagnostics, and Medical and Experimental Mammalian Genetics. Since 2009 he has collaborated with other researchers and has won several research grants.

Administrative Role:

Animal Facility Manager and Head, Production & Supply

Research Interests:

1. Laboratory Animal Science and Technology, model animal development and establishment of well-defined animals for biomedical research

2. Phytotherapy and drug development; In vivo evaluation/characterization of some tropical medicinal plants

3. Medical and experimental mammalian genetics with special interest in uterine leiomyoma (Fibroids) and benign prostate hyperplasia (BPH) studies.

Projects:

1.      Anticonvulsant activity-guided fractionation of Synedrellanodiflora(l) Gaertn whole plant extract.Building Stronger Universities Initiative Platform on Human Health (BSU-PHH), College of Health Sciences, University of Ghana
Role: Co-PI

2.      Investigation into anti-asthmatic potential of regular consumption of natural cocoa powder in ovalbumin or IgE sensitized guinea-pigs. Building Stronger Universities Initiative Platform on Human Health (BSU-PHH), College of Health Sciences, University of Ghana
Role: Co-PI

 3.      Screening Ghanaian medicinal plants for antipsychosis properties. University of Ghana Research Grant
Role: Co-PI

 4.      Collaborator: Observational study: the effect of the aqueous root extract of Croton membranaceus on the treatment of Benign Prostate Hyperplasia and Prostate Cancer. University of Ghana Research Grant
Role: Collaborator

 5.      Intra-ACP Academic mobility scheme project title Enhancing community of practice in one health for infectious diseases through postgraduate training. European Commission – Africa, Caribbean and Pacific (ACP) - Education, Audiovisual and Culture Executive Agency funded project worth 2,000,000.00
Role: Member of Ghanaian team

 6.      Pharmacological study of the antinociceptive effect of Synedrellanodiplora in neuropathic pain. IFS grant.
Role: Co-PI

 7.      Developing an alternate anti-epileptic product from medicinal plants: exemplifying utilization of natural resources for quality health. University of Ghana Research Grant.
Role: Co-PI

 8.      National Research Network Biomed (NRN Biomed) One Health Ghana Consortium. ACP-EU Grant for enhanced research into infectious diseases.
Role:  Member, Coordinating Team

 9.      University of Ghana Grant for research into the effect of some tropical medicinal plants on prostate and uterine leiomyoma.
Role: Co-PI

 

Publications:

1.      Samuel Adjei, Patrick Amoateng, DorcasOsei-Safo,Clement Sasu, Benoit BangaN’guessan, Phyllis Addo, Isaac Asiedu-Gyekye. Sub-acute toxicity of a hydro-ethanolic whole plant extract of Synedrellanodiflora (L)Gaertn in rats. International Journal of Green Pharmacy 8 (4), 271 ~ 275 (2014)

2.      Daniel K. Afriyie, George A. Asare, K. Bugyei, Samuel Adjei, Jiu-mao Lin a, Jun Peng a, Zhen-feng Hong. Treatment of benign prostatic hyperplasia with Croton membranaceus in an experimental animal model. Journal of Ethnopharmacology 157, 90 ~ 98 (2014)

3.      D. K. Afriyie, G. A. Asare, K. Bugyei, I. J. Asiedu-Gyekye, R. Tackie&S. Adjei. Prostate-specific targeting of the aqueous root extract of Croton membranaceus in experimental animals. Andrologia  46, 753 ~ 760 (2014)

4.      Awortwe C, Asiedu-Gyekye IJ, Nkansah E, Adjei S. Unsweetened natural cocoa has anti-asthmatic potential Int J ImmunopatholPharmacol, 27 (2), 203 ~ 212 (2014)

5.      S. Adjei, P. Amoateng, D. Osei-Safo, B. Ahedor, B.B. N’guessan, P. Addo and I.J. Asiedu-GyekyeBiochemical and haematological changes following an acute toxicity study of a hydro-ethanolic whole plant extract of Synedrellanodiflo-ra (L) Gaertn in male Sprague-Dawley rats. Journal of Medical and Biomedical Sciences 3(1): 31 ~ 37 (2014)

6.      Asiedu-Gyekye Isaac Julius, Awortwe Charles, NyamekyeEffah Samuel, Antwi Daniel Ansong, SeiduMahmood, Adjei Samuel, BangaN’guessan Benoit Kwame, Amoateng Patrick, Nkansah Edwin. Nutraceutical with Anti-Inflammatory Activity for the Management of Airway Remodeling in Bronchial Asthma: Kalanchoeintegra Var. Crenata (Andr.) Cuf Leaf Extract. Pharmacology & Pharmacy, 5, 250 ~ 261 (2014)

7.      Asiedu-Gyekye Isaac Julius, Awortwe Charles, TagoeNiiAryee Benjamin, Antwi Daniel Ansong, Adjei Samuel, EduseiDwamena Isaac, Benoit N’guessanBanga Kwame, Amoateng Patrick and Nkansah Edwin. Preliminary Investigation of the Anti-asthmatic Potential of KalanchoeintegraLeaf ExtractUsing a Model of Allergic Airway Inflammation. European Journal of Medicinal Plants 4(5): 542 ~ 562 (2014)

8.      A. A. Appiah, W. A. Asomaning, I. V. Oppong, G. Duker-Eshun, J. Clement, L. K. N. Okine, G. Achel, O. Gyampo, S. Adjei, A. K. Nyarko, F. A. Aboagye, D. A. Edoh, Prospects of Croton membranaceus for Prostate Health in African Natural Plant Products Volume II: Discoveries and Challenges in Chemistry, Health, and Nutrition Chapter 6, pp 79 ~ 92. Copyright © 2013 American Chemical Society

9.      Antwi Daniel A., Asiedu-Gyekye Isaac J., Awortwe Charles, Adjei Samuel, Addo Phyllis,A Single Oral High Dose Toxicity Study of Kalanchoe Integra var. crenata (Andr.) Cuf Leaf Extract In ICR Mice: Histopathological and Biochemical changes. Int. J. Med. and Pharm. Sc. 3 (9): 8 ~ 17 (2013)

10.  George AwukuAsare, KwasiBugyei, Irene Fiawonu, Isaac Julius Asiedu-Gyekye, Ben Gyan, Samuel Adjei, Phyllis Addo, Lydia Otu-Nyarko, Alexander Nyarko. Male rat hormone imbalance, testicular changes and toxicity associated with aqueous leaf extract of an antimalarial plant: Phyllanthusniruri.Pharm. Biol. 51 (6): 691 ~ 699 (2013)

11.  Afriyie DK, Asare GA, Bugyei K, Asiedu-Gyekye I, Gyan BA, Adjei S, Addo P, Sittie A, Nyarko AK. Anti-atherogenic and anti-ischemic potentials of Croton membranaceus observed during sub-chronic toxicity studies. Pharmacog Res 5 (1):10 ~ 16 (2013)

12.  George AwukuAsare, Ben Gyan, KwasiBugyei, Samuel Adjei, RazakMahamaa, Phyllis  Addob, Lydia Otu-Nyarkoa, Edwin Kwame Wiredua, Alexander Nyarko. Toxicity potentials of the nutraceuticalMoringaoleifera at supra-supplementation levels. Journal of Ethnopharmacology 139: 265 ~ 272 (2012)

13.  G.A. Asare, K. Bugyei, A. Sittie, E.S. Yahaya, B. Gyan, S. Adjei, P. Addo, E.K. Wiredu, D.N. Adjei and A.K. Nyarko. Genotoxicity, cytotoxicity and toxicological evaluation of whole plant extracts of the medicinal plant Phyllanthusniruri (Phyllanthaceae). Genetics and Molecular Research 11 (1): 100-111 (2012)

14.  George A. Asare, A. Sittie, K. Bugyei, Ben A. Gyan, Samuel Adjei, Phyllis Addo, Edwin K. Wiredu, Alex K. Nyarko, Lydia S. Otu-Nyarko, David Nana Adjei. Acute toxicity studies of Croton membraneous root extract. Journal of Ethnopharmacology134 (3):938–943 (2011)

15.  George Awuku ASARE, Phyllis ADDO, Kwasi BUGYEI, Ben GYAN, Samuel ADJEI, Lydia Serwaa OTU-NYARKO, Edwin Kwame WIREDU, Alexander NYARKO.  Acute toxicity studies of aqueous leaf extract of Phyllanthusniruri. Interdiscip. Toxicol. 4(4): 206 ~ 210 (2011).

16.  Samuel Adjei, Akira Sato, Takahiro Nagase, Kazumi Matsubara, Yoichi Matsuda, Takao Namikawa and Akira Ishikawa.  A genetic linkage map of the house musk shrew, Suncusmurinus, constructed with PCR-based and RFLP markers. Experimental Animals 57: 129 ~ 134 (2008).

17.  Samuel Adjei and Akira Ishikawa. A novel set of microsatellite loci linkage-mapped in the house musk shrew, Suncusmurinus. Experimental Animals 56: 51~ 56 (2007).

18.  Samuel Adjei, Akira Sato, Shigekazu Tanaka, Eiji Kobayashi, Kazuaki Tanaka,TakaoNamikawa and Akira Ishikawa. Development and characterization of CATS markers for genetic linkage mapping in the house musk shrew, Suncusmurinus.Experimental Animals 54: 173 ~180 (2005).

19.  Phyllis Addo, Alfred Dodoo, Samuel Adjei and BawaAwumbilla. Optimal duration of male-female expposure to optimise conception in the grasscutter (Thryonomysswinderianus). Livestock Research for Rural Development 15, January, 2003. Online publication available at http://www.cipav.org.co/lrrd.

20.  Phyllis Addo, Alfred Dodoo, Samuel Adjei and BawaAwumbilla.

Determination of the ovulatory mechanism of the grasscuter (Thryonomysswinderianus). Animal Reproductive Science 71, 125 ~ 137 (2002).

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+233 030 2501178/79

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