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Name:

Prof. Kwadwo A. Koram, MB, ChB, PhD

 

Email address:

kkoram@noguchi.ug.edu.gh

Telephone:

+233-302-501178/9 .

+233-302-501180

Fax:

+233 -302-502182

Department:

Administration (Epidemiology)

Biography

Professor Kwadwo Ansah Koram is the current Director of the Noguchi Memorial Institute for Medical Research (NMIMR and also serves as the chair of the Inter Agency Committee on Malaria Control. 

 

He graduated from the University of Ghana Medical School in 1982 and worked as a medical officer in Bawku Hospital, a rural and deprived community of the country after house job at the Korle-Bu Teaching Hospital.  During his time at Bawku his interest in public health and epidemiology was kindled as a result of the direct experience of seeing a large proportion of children dying from infectious causes such as malaria and measles despite the availability, then, of adequate treatment and known preventive tools as well as a very good vaccine.

 

Dr. Koram was inspired to specialise in Public Health and Epidemiology and obtaineda PhD from the London School of Hygiene and Tropical Medicine in 1993. Thereafter he worked as a research fellow at NMIMR with focus on malaria, measles and Buruli Ulcer.  He has undertaken several large immune-epidemiological studies on malaria in Ghana and conducted field trials of new interventions including clinical trials. He conducted the pivotal studies that provided the evidence for change in the anti malaria treatment policy in the country in 2005 and served as the chair of the Task Force for antimalarial treatment policy of the National Malaria Control Program. He has since then continued with therapeutic efficacy studies for the new ACTs.

 

He serves on several international advisory boards including the IDMC for the first large scale trial of the malaria vaccine, RTS,S.

 

Administrative Role

Director

Research Interests

·         Epidemiology and Control of Malaria

·         Immuno-epidemiology of malaria, including understanding host parasite interactions

·         Parasite responses to treatment; drug resistance

·         Epidemiology of BU, including transmission

 

 

Projects:[KK1] 

a)      Leverhulme-Royal Society Award # AA110050 (PIs G. Awandare and D. Conway).  Alternative molecular mechanisms for erythrocyte invasion by Plasmodium falciparum in Ghana

 

b)      NIH/Fogarty International Centre 1R01TW009167 (PI, G. Awandare).  Role of Complement Receptor 1 (CR1) in erythrocyte invasion by P. falciparum in semi-immune Ghanaians

 

c)      Rapid Mortality Monitoring BDR+.  Project to establish and validate a community based mortality assessment for children under 5 years. 

Funding Agency:  Sponsored by CIDA and WHO /Health Metrics Network

 

d)     WANETAM.  West African Network of Excellence on TB, AIDs and Malaria. EDCTP funded project to establish nodes of excellence for clinical trials in Malaria, TB, HIV/AIDS. (Ghana Malaria Component).

 

e)      NIAID /NIH Contract No. HHSN266200400016C.  Malaria Vaccines: Clinical Research and Trial Sites in Endemic Areas.

To delineate the Clinical Epidemiology of P. falciparum infections in preparation for malaria vaccine trials in Ghana.  Continuation of NIAID /NIH

 

 

 

Publications:

 1.      Anum D, Kusi KA, Ganeshan H, Hollingdale MR, Ofori MF, Koram KA, Gyan BA, Adu-Amankwah S, Badji E, Huang J, Belmonte M, Banania GJ, Kwofie TB, Villasante E, Dodoo D, Sedegah M. Measuring naturally acquired ex vivo IFN-γ responses to Plasmodium falciparum cell-traversal protein for ookinetes and sporozoites (CelTOS) in Ghanaian adults. Malaria Journal. 2015 Jan 21;14:20. doi: 10.1186/s12936-014-0539-5.

2.      Mitsuko Suzuki , Nguyen Huu Tung, Kofi D. Kwofi, Richard Adegle, Michael Amoa-Bosompem, Maxwell Sakyiamah, Frederick Ayertey, Kofi Baffour-Awuah Owusu, Isaac Tuffour, Philip Atchoglo, Kwadwo Kyereme Frempong, William K. Anyan, Takuhiro Uto, Osamu Morinaga, Taizo Yamashita, Frederic Aboagye, Alfred Ampomah Appiah, Regina Appiah-Opong, Alexander K. Nyarko, Shoji Yamaoka, Yasuchika Yamaguchi,Dominic Edoh, Kwadwo Koram, Nobuo Ohta, Daniel A. Boakye, Irene Ayi and Yukihiro Shoyama. New anti-trypanosomal active tetracyclic iridoid isolated from Morinda lucida Benth. Bioorganic & Medicinal Chemistry Letters.2015, 25 (15): 3030–3033.

 

3.      Kingsley Badu, Ben Gyan, Maxwell Appawu, Daniel Mensah, Daniel Dodoo, Guiyun Yan, Chris Drakeley, Guofa Zhou, Ellis Owusu-Dabo and Kwadwo Ansah Koram. Serological evidence of vector and parasite exposure in Southern Ghana: the dynamics of malaria transmission intensity. Parasites & Vectors (2015) 8:251.DOI 10.1186

 

  1. Kenu E, Nyarko K.M., Seefeld L, Ganu V, Käser M, Lartey M, Calys-Tagoe B.N., Koram K.A., Adanu R, Razum O, AfariE, Binka F.N., Risk factors for buruli ulcer in Ghana-a case control study in the Suhum-Kraboa-Coaltar and Akuapem South Districts of the eastern region. PLoS Negl Trop Dis. 2014 Nov 20;8(11):e3279. doi: 10.1371/journal.pntd.0003279. eCollection 2014 Nov. PubMed PMID: 25411974; PubMed Central PMCID: PMC4238991.

 

  1. Malaria Genomic Epidemiology Network; Malaria Genomic Epidemiology Network. Reappraisal of known malaria resistance loci in a large multicenter study. Nat Genet. 2014 Nov;46(11):1197-204. doi: 10.1038/ng.3107. Epub 2014 Sep 28. PubMed PMID: 25261933.

 

 

6.      Tung N.H., Suzuki M, Uto T, Morinaga O, Kwofie K.D., Ammah N, Koram K.A., Aboagye F, Edoh D, Yamashita T, Yamaguchi Y, Setsu T, Yamaoka S, Ohta N, Shoyama Y. Anti-trypanosomal activity of diarylheptanoids isolated from the bark of Alnus japonica. Am J Chin Med. 2014;42(5):1245-60. doi: 10.1142/S0192415X14500785. Epub 2014 Sep 1. PubMed PMID: 25178281.

 

7.      de-Graft Aikins A, Kushitor M, Koram K.A., Gyamfi S, Ogedegbe G. Chronic non-communicable diseases and the challenge of universal health coverage: insights from community-based cardiovascular disease research in urban poor communities in Accra, Ghana. BMC Public Health. 2014;14 Suppl 2:S3. doi: 10.1186/1471-2458-14-S2-S3. Epub 2014 Jun 20. PubMed PMID: 25082497; PubMed Central PMCID: PMC4120153.

  1. White M.T., Griffin J.T., Akpogheneta O, Conway D.J., Koram K.A., Riley E.M., Ghani A.C.. Dynamics of the antibody response to Plasmodium falciparum infection in African children. J Infect Dis. 2014 Oct 1;210(7):1115-22. doi: 10.1093/infdis/jiu219. Epub 2014 Apr 8. PubMed PMID: 24719471.

 

  1. Kusi KA, Bosomprah S, Dodoo D, Kyei-Baafour E, Dickson EK, Mensah D, Angov E, Dutta S, Sedegah M, Koram KA. Anti-sporozoite antibodies as alternative markers for malaria transmission intensity estimation. Malar J. 2014 Mar 17;13:103. doi: 10.1186/1475-2875-13-103. PubMed PMID: 24635830; PubMed Central PMCID: PMC3995447.
  2. Sanuade OA, Anarfi JK, Aikins A deGraft, Koram KA. Patterns of cardiovascular disease mortality in Ghana: a 5- year review of autopsy cases at Korle-Bu Teaching Hospital. Ethn Dis. 2014 Winter;24(1):55-9. PubMed PMID: 24620449.
  3. Dosoo DK, Asante KP, Kayan K, Adu-Gyasi D, Osei-Kwakye K, Mahama E, Danso S, Amenga-Etego S, Bilson P, Koram KA, Owusu-Agyei S. Biochemical and hematologic parameters for children in the middle belt of Ghana. Am J Trop Med Hyg. 2014 Apr;90(4):767-73. doi: 10.4269/ajtmh.13-0098. Epub 2014 Mar 3. PubMed PMID: 24591437; PubMed Central PMCID: PMC3973528.
  4. Greenwood B, Koram KA. Malaria control in Africa: progress but still much to do. Lancet. 2014 May 17;383(9930):1703-4. doi: 10.1016/S0140-6736(14)60044-1. Epub 2014 Feb 20. PubMed PMID: 24559538.
  5. Quashie NB, Duah NO, Abuaku B, Quaye L, Ayanful-Torgby R, Akwoviah GA, Kweku M, Johnson JD, Lucchi NW, Udhayakumar V, Duplessis C, Kronmann KC, Koram KA. A SYBR Green 1-based in vitro test of susceptibility of Ghanaian Plasmodium falciparum clinical isolates to a panel of anti-malarial drugs. Malar J. 2013 Dec 17;12:450. doi: 10.1186/1475-2875-12-450. PubMed PMID: 24341604; PubMed Central PMCID: PMC3878558.
  6. Norman PJ, Hollenbach JA, Nemat-Gorgani N, Guethlein LA, Hilton HG, Pando MJ, Koram KA, Riley EM, Abi- Rached L, Parham P. Co-evolution of human leukocyte antigen (HLA) class I ligands with killer-cell immunoglobulin-like receptors (KIR) in a genetically diverse population of sub-Saharan Africans. PLoS Genet. 2013 Oct;9(10):e1003938. doi: 10.1371/journal.pgen.1003938. Epub 2013 Oct 31. PubMed PMID: 24204327; PubMed Central PMCID: PMC3814319.
  7. Duah NO, Matrevi SA, de Souza DK, Binnah DD, Tamakloe MM, Opoku VS, Onwona CO, Narh CA, Quashie NB, Abuaku B, Duplessis C, Kronmann KC, Koram KA. Increased pfmdr1 gene copy number and the decline in pfcrt and pfmdr1 resistance alleles in Ghanaian Plasmodium falciparum isolates after the change of anti-malarial drug treatment policy. Malar J. 2013 Oct 30;12:377. doi: 10.1186/1475-2875-12-377. PubMed PMID: 24172030; PubMed Central PMCID: PMC3819684.
  8. Chinbuah MA, Adjuik M, Cobelens F, Koram KA, Abbey M, Gyapong M, Kager PA, Gyapong JO. Impact of treating young children with antimalarials with or without antibiotics on morbidity: a cluster-randomized controlled trial in Ghana. Int Health. 2013 Sep;5(3):228-35. doi: 10.1093/inthealth/iht021. PubMed PMID: 24030274.
  9. Asante KP, Owusu-Agyei S, Cairns M, Dodoo D, Boamah EA, Gyasi R, Adjei G, Gyan B, Agyeman-Budu A, Dodoo T, Mahama E, Amoako N, Dosoo DK, Koram KA, Greenwood B, Chandramohan D. Placental malaria and the risk of malaria in infants in a high malaria transmission area in ghana: a prospective cohort study. J Infect Dis. 2013 Nov 1;208(9):1504-13. doi: 10.1093/infdis/jit366. Epub 2013 Aug 1. PubMed PMID: 23908483; PubMed Central PMCID: PMC3789576.
  10. Dadzie S, Boakye D, Asoala V, Koram K. A., Kiszewski A, Appawu M. A community-wide study of malaria reduction: evaluating efficacy and user-acceptance of a low-cost repellent in northern Ghana. Am J Trop Med Hyg. 2013 Feb;88(2):309-14. doi: 10.4269/ajtmh.2012.12-0370. Epub 2012 Dec 18. PubMed PMID: 23249683; PubMed Central PMCID: PMC3583322.
  11. Abuaku B, Duah N, Quaye L, Quashie N, Koram K. A. Therapeutic efficacy of artemether-lumefantrine combination in the treatment of uncomplicated malaria among children under five years of age in three ecological zones in Ghana. Malar J. 2012 Nov 22;11:388. doi: 10.1186/1475-2875-11-388. PubMed PMID: 23173737; PubMed Central PMCID: PMC3519607.
  12. Duah NO, Quashie NB, Abuaku BK, Sebeny PJ, Kronmann KC, Koram KA. Surveillance of molecular markers of Plasmodium falciparum resistance to sulphadoxine-pyrimethamine 5 years after the change of malaria treatment policy in Ghana. Am J Trop Med Hyg. 2012 Dec;87(6):996-1003. doi: 10.4269/ajtmh.2012.12-0202. Epub 2012 Oct 8. PubMed PMID: 23045251; PubMed Central PMCID: PMC3516103.
  13. Ibrahim F, Dosoo D, Kronmann KC, Ouedraogo I, Anyorigiya T, Abdul H, Sodiomon S, Owusu-Agyei S, Koram K.A. Good clinical laboratory practices improved proficiency testing performance at clinical trials centers in Ghana and Burkina Faso. PLoS One. 2012;7(6):e39098. doi: 10.1371/journal.pone.0039098. Epub 2012 Jun 29. PubMed PMID: 22768062; PubMed Central PMCID: PMC3387181.

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