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+233 030 2501178/79

Name:

Dr. Irene Ayi

Email address:

iayi@noguchi.ug.edu.gh

Telephone:

+233-302-501178/9

Cell phone:

+233-243670493; +233-262670493

Fax:

+233 302 502182

Department:

Parasitology

 

 

Short Biography

Dr. Irene Ayi obtained a Ph.D. in Medical Sciences (Environmental Parasitology) from the Tokyo Medical and Dental University, Tokyo, Japan in 2005. Currently a Research Fellow, she has worked at the Noguchi Memorial Institute for Medical Research in various capacities since 1991. She has been involved in the training of young researchers through mentorship of interns and graduate/post-graduate students’ thesis research supervision. In the past 5 years, she has supervised four PhDs, 16 MPhils and several interns from Universities across Ghana and beyond. She has been involved in consultancy works in the area of evaluation of rapid diagnostic tests for parasitic diseases and snake venom anti-serum potency testing as well as malacology. Dr. Ayi serves on a number of Boards and Committees of the College of Health Sciences and the University of Ghana. She serves as external examiner for post-graduate studies for some universities in Ghana. She served as the WHO temporary advisor on the WHO Consultation on guidelines for efficacy testing and operational use of molluscicides for schistosomiasis control in October 2015. She is passionate about contributing to the career development and growth of young research scientists, particularly, women to make a positive impact in their generation. Dr. Ayi was born on 10th May 1964, a Ghanaian and married with three children.

Administrative Role:

Former Head of Department (2012 - 2015)

Research Interests:

·      Transmission dynamics, host-parasite relationships, co-infections with other pathogens, prevention and control of Neglected Tropical Parasitic Diseases/zoonotic and infectious parasitic diseases of public health concern including Schistosomiasis, Soil-Transmitted Helminthiasis, Toxocariasis, Trypanosomiasis, Amoebiasis, Toxoplasmosis, Leishmaniasis, Babesiosis, and Malaria.

·      Development of tools for differential and non–invasive diagnostics for common parasitic diseases.

·      Drug development from natural products against common parasitic diseases

Promotion of comprehensive school health through control of common parasitic diseases in relation to water and sanitation.)

Projects (within the past 5 years):

Ongoing

·     Surveillance of Pathogens Associated with Diarrhoea Outbreaks in Ghana: Detection and Molecular Characterization of Diarrhoea causing Parasites. (2015 - 2019). Funding agency: AMED via Tokyo Medical and Dental University (Role: PI)

·     Research on Medicinal plant extracts for treatment of NTD in Ghana.(2015 - 2019). Funding agency: AMED via Tokyo Medical and Dental University (Role: Co-PI)

·     The Role of Intra-Cellular Protozoan Parasites: Toxoplasma gondii and Babesia spp besides Plasmodium in Fevers of unknown Origin in Accra (Duration: 2 years) (Role: PI)

·     A randomised control trial examining the impact of school feeding on nutrition, education, agriculture and other social outcomes in Ghana End-line survey (2015 - 2017) Funding:  Partnership for Child Development, Imperial College, London. PI: Dr. Lesley Drake; (Role: Co-PI, Parasitology)

·     Screening of selected medicinal plants in Ghana for anti-Leishmania spp properties (2014 – 2016) Funding: NMIMR Post-doctoral Fellowship under the Graduate Research Scheme US$3,000 ; JICA/JST (Role: Co-PI/Supervisor [MPhil])

·     Characterization of cellular responses to Toxoplasma gondii infection in immune-competent and immune-compromised individuals in Ghana (2014 – 2016) Funding NMIMR Post-doctoral Fellowship under the Graduate Research Scheme US$4,000; TMDU (Role: Co-PI/Supervisor; [M.Phil])

·     Anti-Schistosoma Antibody Profiling of Persons Living in a Schistosomiasis Endemic Area Pre- and Post -Praziquantel Treatment (2014 – 2016) Funding NMIMR Post-doctoral Fellowship under the Graduate Research Scheme US$4,000 (Role: PI/Supervisor [MPhil] )

Surveillance of arthropod-borne viruses in Ghana based on virome analysis of hematophagous arthropods (2015 – 2017) (Funding: Ministry of Education, Culture, Sports and Technology, Japan, Ministry of Health, Labour and Welfare, Japan - US$48,100) (Role: Collaborator)

 

Recently Completed

·     Control of Parasitic Diseases in Ghana: Establishment of Epidemiological Database for Parasitic Diseases in Ghana (2009 - 2015) – Funded by Japan Ministry of Education, Culture, Sports, Science and Technology (MEXT) via Tokyo Medical and Dental University (TMDU) US$80,000  (Role: Co-PI)

o  Toxoplasmosis Research - Immuno- and molecular epidemiology, diagnosis and strain genotyping (Role: PI)

o  Congenital Transmission of Toxoplasma gondii and Plasmodium falciparum co-infections in the Kumasi Metropolis (Role: PI/Supervisor [M.Phil])

·     Anti-parasitic drug discovery-related research

o   Studies of Anti-viral anti-parasitic Compounds from Selected Ghanaian Medicinal Plants (SATREPS project) “ (2011 - 2015) Funded by Government of Japan via JST/JICA. US$464,570 (Role: Co-investigator on the anti-parasitic aspects)

o   Screening selected medicinal plants in Ghana for anti-Plasmodium spp properties (2013 – 2015) Funding: NMIMR Post-doctoral Fellowship under the Graduate Research Scheme US$4,000; JICA/JST (Role: Co-PI/Supervisor; [MPhil)

·     Studies on the Mother-To-Child Transmission Risk of Toxoplasma gondii Infection among Pregnant Women in the Greater Accra Region (PI/Supervisor: [MPhil project]) - 2014

·     Detection and Genotyping of Toxoplasma gondii in HIV Patients and Blood Donors (PI/Supervisor [MPhil]) 2013

·     Toxoplasmosis and malaria parasites co-infection in pregnant women and the impact on birth outcomes (PI/supervisor; [MPhil]) - 2014

 

Schistosomiasis research

·     The Targeted Development of a New Generation Vaccine for Schistosomiasis (TheSchistoVac) – A multi-national project (2010-2014) - Funded by EU and coordinated byLeiden University Medical Centre (LUMC), Netherlands US$68,762 PI: Prof. Danel A. Boakye (Role: Field coordinator for Ghana/Co-investigator)

·     Intensity of schistosomiasis by egg count and measurement of eosinophil cationic protein levels as possible biomarkers for estimating intensity of infection before and after Praziquantel treatment (PI/Supervisor; [MPhil])

 

Nutrition-; Water and Sanitation-related and other projects

·     A randomised control trial examining the impact of school feeding on nutrition, education, agriculture and other social outcomes in Ghana (2012 – 2014) Funding: US$350,000 Dubai Cares via the Partnership for Child Development (PCD), Imperial College, London. PI: Dr. Lesley Drake; Role: Co-PI, Parasitology)

·     Effect of Fish meal and Vitamin C on the Iron Status of Ghanaian Children Consuming Cowpea-based Food (2009-2013) - Training Grant (TG), PhD Thesis Project (Funded by Nestle Foundation, Switzerland – US$20,000; African Doctoral Dissertation Fellowship, Nairobi, of the African Population and Health Research Centre under the auspices of the Canadian Development Funding Agency – US$7,500; College of Health Sciences, University of Ghana – GHS 2,000). PI: Dr. Godfred Egbi (Role: Co-investigator/Co- supervisor)

·     SUSA Ghana Project (WP4): Peri-urban Environment, Sanitation and Health – Associated Health Risk Factors in Solid Waste Handling in a Peri-urban Community in Ghana, West Africa (2011-2015) PhD Thesis Project US$125,000. PI: Dr. Mawuli Dzodzomenyo (SPH) (Role: Co-supervisor)

The SaniPath Study: Assessment of Faecal Exposure Pathways in Low-Income Urban Settings (August 2010 – December 2013) A multi-national and multi-institutional collaborative study with Emory University, Atlanta, GA S$95,738 PI: Prof. George Armah (Role: Co-investigator, Parasitologist)

Publications:

1.     Reginald Arthur-Mensah Jnr, Emmanuel Awusah Blay, John Larbi, Takashi Suzuki, Nobuo Ohta, Irene Ayi,  Effectiveness of SP-IPTp for malaria and evidence for the need of T. gondii infection preventive policy during pregnancy in Ghana  Journal of Infectious Diseases and Epidemiology  Manuscript ID: JIDE_JB96223126. In press

2.     Michael Amoa-Bosompem, Mitsuko Ohashi, Mba-Tihssommah Mosore, Jeffrey Agyapong, Nguyen Huu Tung, Kofi Dadzie Kwofie, Frederick Ayertey; Kofi Baffour-Awuah Owusu, Isaac Tuffour, Philip Atchoglo, Georgina Isabella Djameh; Faustus Akankperiwen Azerigyik; Senyo Kojo Botchie; William Kofi Anyan, Regina Appiah-Opong, Takuhiro Uto, Osamu Morinaga, Alfred Ampomah Appiah, Irene Ayi, Yukihiro Shoyama, Daniel Adjei Boakye, Nobuo Ohta  In vitro anti-Leishmania activity of tetracyclic iridoids from Morinda lucida, benth. Tropical Medicine and Health 2016, Manuscript ID: TMAH-D-16-00019R1. In press

3.     Ato Kwamena Tetteh, Joseph Otchere, Langbong Bimi, Irene Ayi  Evaluation of field recognizable morbidity indicators of Schistosoma haematobium infection among primary school children in Ghana. ISSN 2304-3415, Russian Open Medical Journal Hygiene and Environmental Health 2016; 5(3):1-9. Article CID e0303  DOI: 10.15275/rusomj.2016.0303

4.     Kwofie, K. D., Ghansah, A., Osei, J. H. N., Frempong, K. K., Obed, S., Frimpong, E. H., Boakye, D. A., Suzuki, T., Ohta, N., & Ayi, I. (2016) Indication of Risk of Mother-to-Child Toxoplasma gondii Transmission in the Greater Accra Region of Ghana Journal: Maternal and Child Health Journal doi: 10.1007/s10995-016-2084-z Published online: July 2016

5.     Ayi I, Sowah AO-K, Blay EA, Suzuki T, Ohta N, Ayeh-Kumi PF.  Toxoplasma gondii infections among pregnant women, children and HIV seropositive persons in Accra, Ghana. Trop Med Hlth. (2016) 44:17 DOI 10.1186/s41182-016-0018-5

6.     Abu EK, Boampong JN, Amoabeng JK, Ilechie AA, Kyei S, Owusu-Ansah A, Boadi-Kusi SB, Amoani B, Ayi I.  Epidemiology of Ocular Toxoplasmosis in Three Community Surveys in the Central Region of Ghana, West Africa Ophthalmic Epidemiol. 2016;23(1):14-9. doi: 10.3109/09286586.2015.1089579. Epub 2016 Jan 20.

7.     Gelli A., Masset E., Folson G., Kusi A., Arhinful D. K., Asante F., Ayi I., Bosompem K. M., Watkins K., Abdul-Rahman L., Agble R., Ananse-Baden G., Mumuni D., Aurino E.,  Fernandes M., and Drake L.  Evaluation of alternative school feeding models on nutrition, education, agriculture and other social outcomes in Ghana: rationale, randomised design and baseline data.  Trials  (2016) 17:37   DOI: 10.1186/s13063-015-1116-0

8.     Ayi I., Kwofie K. D., Blay E. A., Osei J. H. N.,  Frempong K. K., Koku R., Ghansah A., Lartey M., Suzuki  T., Boakye D. A., Koram K. A., and Ohta N.  Clonal types of Toxoplasma gondii among immune compromised and immune competent individuals in Accra, Ghana.  Parasitology International 65, January 8 2016, Pages 238-244. DOI:10.1016/j.parint.2016.01.004 http://www.sciencedirect.com/science/article/pii/S1383576916000052

9.     Karasawa S., Yoza K., Tung N. H., Uto T., Morinaga O., Suzuki M., Kwofie K. D., Amoa-Bosompem M., Boakye D. A. Ayi I., Adegle R., Sakyiamah M., Ayertey F., Aboagye F., Appiah A. A., Owusu K. B.-A., Tuffour I., Atchoglo P., Frempong K. K., Anyan W. K., Appiah-Opong R., Nyarko A. K., Yamashita T., Yamaguchi Y., Edoh D., Koram K., Yamaoka S., Ohta N., Shoyama Y.  Determination of the absolute configuration of the novel anti-trypanosomal iridoid molucidin isolated from Morinda lucida by X-ray analysis. Tetrahedron Letters Volume 56, Issue 52, 30 December 2015, Pages 7158–7160

10. Blay E. A., Ghansah A., Otchere J., Koku R., Kwofie K. D., Bimi L., Suzuki T., Ohta N., Ayi I.  Congenital toxoplasmosis and pregnancy malaria detection post-partum: Effective diagnosis and its implication for efficient management of congenital infection. Parasitology International 8 August 2015 64 (2015) 603–608

11. Egbi G., Ayi I., Saalia F. K., Zotor F., , Adom T., Harrison E., Ahorlu C. K., and Steiner-Asiedu M. Impact of Cowpea-Based Food Containing Fish Meal Served With Vitamin C–Rich Drink on Iron Stores and Hemoglobin Concentrations in Ghanaian Schoolchildren in a Malaria Endemic Area Food and Nutrition Bulletin 2015, Vol. 36(3) 264-275 DOI: 10.1177/0379572115596253 fnb.sagepub.com

12. Abu E. K., Boampong J. N., Afoakwa R.,  Ameyaw E. O., Ntodie M., and Ayi I.  Visual Outcome in Ocular Toxoplasmosis: A Case Series of 30 Patients from Ghana.  Journal of Clinical and Experimental Ophthalmology 2015 August, 6:4 http://dx.doi.org/10.4172/2155-9570.1000458

13. Suzuki M, Tung N. H., Kwofie K. D., Adegle R., Amoa-Bosompem M., Sakyiamah M., Ayertey F., Owusu K. B., Tuffour I., Atchoglo P., Frempong K. K., Anyan W. K., Uto T., Morinaga O., Yamashita T., Aboagye F., Appiah A. A., Appiah-Opong R., Nyarko A. K., Yamaoka S., Yamaguchi Y., Edoh D., Koram K., Ohta N., Boakye D. A., Ayi I., Shoyama Y.  New anti-trypanosomal active tetracyclic iridoid isolated from Morinda lucida Benth. Bioorganic and Medicinal Chemistry Letters August 2015 1; 25(15):3030-3. doi: 10.1016/j.bmcl.2015.05.003. Epub May 13 2015.

14. Kyei G., Ayi I., Boampong J. N., and Turkson P. K.  Sero-epidemiology of Toxocara canis infection in children attending four selected health facilities in the Central Region of Ghana.  Ghana Medical Journal June 2015 Volume 49, Number 2 77 DOI: http://dx.doi.org/10.4314/gmj.v49i2.3

15. Kretchy J.-P., Dzodzomenyo M., Rheinlӓnder T., Ayi I., Konradsen F, Fobil J. N., and Dalsgaard A.  Exposure, protection and self-reported health problems among solid waste handlers in a Coastal Peri-urban community in Ghana. International Journal of Public Health and Epidemiology ISSN: 2326-7291 Vol. 4 (2), pp. 121-128, February, 2015. Available online at www.internationalscholarsjournals.org © International Scholars Journals

16. Asuming-Brempong E., Gyan B., Amoah A. S., van der Puije W., Bimi L., Boakye D. and Ayi I.  Relationship between eosinophil cationic protein and infection intensity in a schistosomiasis endemic community in Ghana.  Research and Reports in Tropical Medicine.  January 2015 Volume 2015:6 Pages 1-10  DOI: http://dx.doi.org/10.2147/RRTM.S51713

17. Abu E. K., Boampong J. N., Ayi I., Ghartey-Kwansah G., Afoakwa R., Nsiah P. and Blay E..  Infection risk factors associated with seropositivity for Toxoplasma gondii in a population-based study in the Central Region, Ghana. Epidemiol. Infect. 143 (9), July 2015, pp 1904-1912. © Cambridge University Press 2014  doi:10.1017/S0950268814002957 Published online: 06 November 2014

18. Ido E, Suzuki T, Ampofo WK, Ayi I, Yamaoka S, Koram KA, Ohta N. Joint research project on infectious diseases in West-African subregion.  J Disaster Res, 9: 813-817, 2014.

19. Egbi G., Steiner-Asiedu M., Faribu S. K., Ayi I., Ofosu W., Setorglo J., Klobodu S. S., Armar-Klemesu M.  Anaemia among school children older than five years in the Volta Region of Ghana. Pan Afr Med J. 2014; 17(Supp 1):10. http://www.panafrican-med-journal.com/content/series/17/1/10/full. DOI:10.11694/pamj.supp.2014.17.1.

20. Saito J., Nonaka D., Mizoue T., Kobayashi J., Jayatilleke A. C., Shrestha S., Kikuchi K., Haque S. E., Yi S., Ayi I., Jimba M.  Limited potential of school textbooks to prevent tobacco use among students grade 1–9 across multiple developing countries: a content analysis study.  BMJ Open 2013; 3:e002340.  doi:10.1136/bmjopen-2012-002340

21. Boamah D., Kikuchi M., Huy N. T., Okamoto K., Chen H., Ayi I., Boakye D. A., Bosompem K. M., and Hirayama K.  Immunoproteomics Identification of Major IgE and IgG4 Reactive Schistosoma japonicum Adult Worm Antigens using Chronically Infected Human Plasma Tropical Medicine and Health Vol. 40 No. 3, 2012, pp. 89-102 doi:10.2149/tmh.2012-16

22. Boamah D., Ayi I., Yankson K. and Bosompem K. M.  Mouse Monoclonal Antibodies against Human Urinary Protein Sm-UP2IP of Schistosoma mansoni.  Hybridoma (Larchmt). 2012 Jun; 31(3):188-95.

23. Nonaka D., Jimba M., Mizoue T., Kobayashi J., Yasuoka J., Ayi I., Jayatilleke A. C., Shrestha S., Kikuchi K., Haque S. E., Yi S.  Content Analysis of Primary and Secondary School Textbooks Regarding Malaria Control: A Multi-Country Study PLoS ONE | www.plosone.org 6 May 2012 Volume 7  Issue 5  e36629

24. Kwansa-Bentum, B., Ayi I., Suzuki T., Otchere J., Kumagai T., Anyan W.K., Osei H.N., Asahi H., Ofori M.F., Akao N., Wilson M.D., Boakye D.A. and Ohta N.  Plasmodium falciparum isolates from southern Ghana exhibit polymorphisms in the SERCA-type PfATPase6 though sensitive to artesunate in vitro. Mal J 10(1):187 (2011) PMID 21745377

25. Kwansa-Bentum B., Ayi I., Suzuki T., Otchere J., Kumagai T., Anyan W.K., Asahi H., Akao N., Wilson M.D., Boakye D.A., Ohta N.  Administrative practices of health professionals and use of artesunate-amodiaquine by community members for treating uncomplicated malaria in southern Ghana: implications for artemisinin-based combination therapy deployment. Trop Med Int Health 16(10):1215–1224, (2011) PMID 21740487

26. Padonou G. G., Sezonlin M., Gbedjissi G. L., Ayi I., Azondekon R., Djenontin A., Bio-Bangana S., Oussou O., Yadouleton A., Boakye D. and Akogbeto M.  Biology of Anopheles gambiae and insecticide resistance: Entomological study for a large scale of indoor residual spraying in South East Benin Journal of Parasitology and Vector Biology Vol. 3(4), pp. 59-68, 2011 (http://www.academicjournals.org/JPVB ISSN 2141-2510 ©2011 Academic Journals)

27. Ayi I., Nonaka D., Adjovu J. K., Hanafusa S., Jimba M,. Bosompem K. M., Mizoue T., Takeuchi T., Boakye D. A. and Kobayashi J. School-based participatory health education for malaria control in Ghana: engaging children as health messengers Malaria Journal. 9:98, 2010. http://www.malariajournal.com/content/9/1/98 PMID 20398416

28. Ayi I., Edu S. A.A, Apea-Kubi K. A., Boamah D., Bosompem K. M. and Edoh D. Sero-Epidemiology of Toxoplasmosis amongst Pregnant Women in the Greater Accra Region of Ghana. Ghana Medical Journal 43(3):107-14, 2009.

29. Bosompem K. M., Wilson M. D., Anyan W. K., Awazawa T., Hanafusa S., Boakye D. A., Appawu M. A., Ayi I., Boamah D., Asigbee J. K., Quartey J. K., Ogiwara H., Ohta N., Ofori-Adjei D., Nyarko A. and Takeuchi T.. Control of Parasitic Diseases through School-based Health Education and Deworming: A five years activities in Ada-Foah, Ghana. X European Multicolloquium of Parasitology. 978-88-7587-460-5, 2008.

30. Ayi, I., Boateng, N. A. D., Ayeh-Kumi, P. F., Sagoe, K., Asmah, R. H., Akao N. A study on Amoebiasis as an opportunistic infection in HIV/AIDS patients at Korle-Bu Teaching Hospital. Ghana Journal of Allied Health Sciences 1(2):35-42, 2007.

31. Ayi, I., Akao, N., Bosompem, K. M., Akafo, S. K., Clarke, J., Nyador, L., Apea-Kubi, K. and Fujita, K.  Development of membrane-bases tests for the detection of urinary antigens and antibodies in human toxoplasmosis: preliminary studies in Ghanaian patients. Acta Tropica 93, 151-159. 2005.PMID 15652329

32. Bosompem K. M., Ayi I., Anyan W. K., Nkrumah F. K., and Kojima S. A monoclonal antibody-based dipstick assay for urinary schistosomiasis.  Transactions of the Royal Society of Tropical Medicine and Hygiene, 91, 554-556, 1997.

33. Bosompem K. M., Ayi I., Anyan W. K., Nkrumah F. K. and Kojima S. Limited field evaluation of a rapid monoclonal antibody-based dipstick assay for urinary schistosomiasis.  Hybridoma, 15 (6), 443-447, 1996.

34. Bosompem K. M., Arishima T., Yamashita T., Ayi I., Anyan W. K. and Kojima S.  Extraction of Schistosoma haematobium antigens from infected human urine. Acta Tropica, 62(2), 91-103, 1996.

 

Book Chapters

  1. Michael D. Wilson, Dziedzom de Souza and Irene Ayi. (2016) Soil-Transmitted Helminthiasis In John Gyapong, Boakye Boatin (Eds.) Neglected Tropical Diseases - sub-Saharan Africa, In Peter J. Hotez (Series Ed.) Neglected Tropical Diseases, pp289 – 317. ISSN 194-8275, ISSN 2194-8283 (electronic), ISBN 978-3-319-25469-2, ISBN 978-3-319-25471-5 (e-Book) DOI 10.1007/978-3-319-25471-5_12 Library of Congress Control Number: 2015958883 ©Springer International Publishing Switzerland
  2. Irene Ayi, Ato Kwamena Tetteh, Joseph Otchere, Langbong Bimi, Daniel Adjei Boakye (2014) Poly-Parasitism of P. falciparum and Helminthes among School Children in three Peri-Urban Communities in Ghana. In Kwadwo Ansah Koram, Collins K. Ahorlu, Michael D. Wilson, Dorothy Yeboah-Manu, Kwabena Mante Bosompem (Eds.). University of Ghana Readers. ”Towards Effective Disease Control in Ghana: Research and Policy Implications” No. 5 vol 2 Chapter 14 (pp173-189) Ghana, Sub-Saharan Publishers
  3. Kwabena M. Bosompem, William K. Anyan, Daniel Boamah, Stephanie K. Adjovu, Irene Ayi, Joseph Quartey, Joshua Adjovu, Jonas Asigbee, Maxwell A. Appawu, Michael D. Wilson, Daniel A. Boakye, Koichi Morinaka, Hisayoshi Ogiwara, Nobuo Oha and Tsutomu Takeuchi  Towards sustainable control of schistosomiasis and soil-transmitted helminthiasis: Deworming and education at Ada-Foah, Ghana (2014) In Kwadwo Ansah Koram, Collins K. Ahorlu, Michael D. Wilson, Dorothy Yeboah-Manu, Kwabena Mante Bosompem (Eds.). University of Ghana Readers.”Towards Effective Disease Control in Ghana: Research and Policy Implications” No. 5 vol 2 Chapter 16 (pp206-219) Ghana, Sub-Saharan Publishers

 

Patents

Inventors: Shoji YAMAOKA (Tokyo), Nobuo Ohta (Tokyo), Mitsuko Suzuki (Tokyo), Yukihiro Shoyama (Sasebo-shi), Osamu Morinaga (Sasebo-shi), Takuhiro Uto (Sasebo-shi), Nguyen Huu Tung (Sasebo-shi), Kwadwo Ansah Koram (Legon), Kwabena Mante Bosompem (Legon), Alexander Kwadwo Nyarko (Legon), Daniel Adjei Boakye (Legon), Irene Ayi (Legon), Regina Appiah-Opong (Legon), Dominic Adotei Edoh (Koforidua), Laud Kenneth Nii-ayitey Okine (Accra), Frederick Asare Aboagye (Larteh)

·         Title of invention: Novel Compounds Having a Tetracyclic Iridoid Skeleton and an Anti-Trypanosomal Agent Comprising the same as an Active Ingredient. Ref: PH-5727-US (January, 2014).

·         Title of invention: Novel Compounds Having a Tetracyclic Iridoid Skeleton and an Anti-Trypanosomal Agent Comprising the same as an Active Ingredient. Ref: PH 5727-PCT International patent application  (January, 2015)

Application # 20150191484)  http://patents.justia.com/patent/20150191484

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