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Title

Dr.

Name

Kwadwo Asamoah Kusi

Academic Qualification

B.Sc., M.Phil. (Ghana), Ph.D. (Leiden)

Professional Qualification

Immunologist

Email address

akusi@noguchi.ug.edu.gh; kusi.asamoah@gmail.com

Telephone (Office)

+233-302-501178 Ext 2461

Fax number

+233-302-502182

School/Institute

Noguchi Memorial Institute for Medical Research

Department:

Immunology

Biography

Dr. Kwadwo A. Kusi is a Research Fellow with the Immunology Department of NMIMR. He Joined NMIMR in 2003 as an M.Phil. Research student after which he worked as a senior research assistant in the same department from 2005 to 2007. He left NMIMR in 2007 for PhD studies in the Netherlands and returned to NMIMR as one of the first two Fellows under NMIMR’s Postdoctoral training programme in February 2012. He was subsequently appointed Research Fellow in the Immunology Department, NMIMR, in April 2012. He has also, since August 2011, held the position of part-time lecturer in the Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Legon. Dr. Kusi has a PhD in Medicine (Vaccine Immunology, 2012) fromLeiden University, Leiden, The Netherlands. He also has B.Sc. (2000) and M.Phil. (2005) degrees, both in Biochemistry, from the University of Ghana, Legon. He is married to Stella, a graduate teacher with Adonten Senior High School at Aburi and they have two wonderful children; six year old Cheryl and four year old Sean.

Administrative Role

Member, College of Health Sciences Academic Board

Research interests

1.      Humoral and cellular immunology of infectious diseases.

2.      Identification and evaluation of biomarkers of disease progression/transmission.

3.      Identification and evaluation of potential antigenic targets of antibody and T cell immunity to malaria.

4.      Development of immunoassays for the evaluation of infectious disease biomarkers.

Completed research projects

1.      Association of potent T cell responses to HLA class I-restricted CSP and AMA1 epitopes with the risk of P. falciparum infection. UGRF, Principal Investigator.

 

2.      Relationship between antibody recognition by P. falciparum pre-erythrocytic vaccine candidate antigens and clinical and parasitological protection against malaria in an endemic area. US Congressional Funds, Co-Investigator.

On-going projects

1.      Malaria- helminth co-infections in Southern Ghana: issue and challenge in vaccine development against placental malaria. IRD, France. Co-Investigator.

 

2.      Functional immunogenetic correlates of immunity to

Malaria.DANIDA. Co-Investigator.

 

3.      Correlation between histo-blood group antigens and serum antibody response to rotavirus vaccine in Ghanaian children. Funder: Centers for Disease Control and Prevention (CDC) Foundation, USA. 2016 - 2017, Co-investigator.

 

Peer-reviewed publications

1.      Amoako-Sakyi D, Adukpo S, Kusi KA, Dodoo D, Ofori MF, Adjei GO, Edoh DE, Asmah RH, Brown C, Adu B et al. (2016). A STAT6 Intronic Single-Nucleotide Polymorphism is Associated with Clinical Malaria in Ghanaian Children. Genetics & Epigenetics, 8: 7–14 doi:10.4137/GEG.S38307.

 

2.      Ganeshan H, Kusi KA, Anum D, Hollingdale MR, Peters B, Kim Y, Tetteh JKA, Ofori MF, Gyan BA, Koram KA et al (2016). Measurement of ex vivo ELISpot interferon-gamma recall responses to Plasmodium falciparum AMA1 and CSP in Ghanaian adults with natural exposure to malaria. In press

 

3.      AmoahLE, KakaneyC, Kwansa-Bentum Band Kusi KA(2015). Activity of Herbal Medicines on Plasmodium falciparum Gametocytes: Implications for Malaria Transmission in Ghana. PLoSONE, 10 (11): e0142587. doi:10.1371/journal.pone.0142587

 

4.      DonkorAM,Oduro-Mensah D, Ani E, Ankamah E, Nsiah S, Mensah DE, Dickson EK and Kusi KA(2015). In vitro anti-Plasmodial activity of aqueous and ethanolic extractsof Moringaoleiferaand Phyllanthusamarus. Int J of Biol Chem. 9 (4): 198-206, 2015

 

5.      Anum D, Kusi KA, Ganeshan H, Hollingdale MR, Ofori MF, Koram KA, Gyan BA, AduAmankwah S, Badji E, Huang J et al (2015): Measuring naturally acquired ex vivo IFNgamma responses to Plasmodium falciparum cell-traversal protein for ookinetes and sporozoites (CelTOS) in Ghanaian adults. Malar J14:20.

 

6.      Kusi KA, Bosomprah S, Dodoo D, Kyei-Baafour E, Dickson EK, Mensah DA, Angov E, Dutta S, Sedegah M and Koram KA (2014). Anti-sporozoite antibodies as alternative markers for malaria transmission intensity estimation. Malaria Journal 13:103.

 

7.      Adukpo S, Kusi KA, Ofori M ,Tetteh JKA, Amoako-Sakyi D,Goka BQ, Adjei GO, Edoh DA, Akanmori BD, Gyan BA, and Dodoo D (2013).  High plasma levels of soluble intercellular adhesion molecule (ICAM)-1 are associated with cerebral malaria. PLoSONE 8(12): e84181. doi:10.1371/journal.pone.0084181.

 

8.      Kusi KA, Dodoo D, Bosomprah S, van der Eijk M, Faber BW, Kocken CHM and Remarque EJ (2012). Measurement of the plasma levels of antibodies against the polymorphic vaccine candidate apical membrane antigen 1 in a malaria-exposed population. BMC Infectious Diseases, 12:32

 

9.      Kusi KA, Remarque EJ, Riasat V, Walraven V, Thomas AW, Faber BW and Kocken CHM (2011). Safety and immunogenicity of multi-antigen AMA1-based vaccines formulated with CoVaccine HT™ and Montanide ISA 51 in rhesus macaques. Malaria Journal, 10:182

 

10.  Kusi KA, Faber BW, van der Eijk M, Thomas AW, Kocken CHM and Remarque EJ (2011). Immunisation with different PfAMA1 alleles in sequenceinduces clonal imprint humoral responses that are similar to responses induced by the same alleles as a vaccine cocktail in rabbits. Malaria Journal, 10:40

 

11.  Kusi KA, Faber BW, Riasat V, Thomas AW, Kocken CHM and Remarque EJ (2010). Generation of humoral immune responses to multi-allele PfAMA1 allele vaccines; effect of adjuvant and the number of component alleles on the breadth of response. PLoS ONE5(11): e15391. doi:10.1371/journal.pone.0015391

 

12.  Kusi KA, Faber BW, Thomas AW and Remarque EJ (2009). Humoral immune response to mixed PfAMA1 alleles; Multivalent PfAMA1 vaccines induce broad specificity. PLoS ONE4(12): e8110. doi:10.1371/ journal.pone.0008110

 

13.  Courtin D, Oesterholt M, Huismans H, Kusi K, Milet J, Badaut C, Gaye O, Roeffen W, Remarque EJ, Sauerwein R, Garcia A and Luty AJF (2009). The quantity and quality of African Children’s IgG responses to Merozoite Surface Antigens reflect protection against Plasmodium falciparum Malaria. PLoS ONE4(10): e7590. doi:10.1371/journal.pone.0007590

 

14.  Gyan B, Goka BQ, Adjei GO, Tetteh JK, Kusi KA, Aikins A, Dodoo D, Lesser ML, Sison CP, Das S, Howard ME, Milbank E, Fischer K, Rafii S, Jin D and Golightly LM (2009). Cerebral malaria is associated with low levels of circulating endothelial progenitor cells in African children. Am J Trop Med Hyg.80(4): 541-6.

 

15.  Dodoo D, Aikins A, Kusi KA, Lamptey H, Remarque E, Milligan P, Bosomprah S, Chilengi R, Osei YD, Akanmori BD and Theisen M (2008). Cohort study of the association of antibody levels to AMA1, MSP119, MSP3 and GLURP with protection from clinical malaria in Ghanaian children. Malar J7: 142. doi:10.1186/1475-2875-7-142

 

16.  Kusi KA, Gyan BA, Goka BQ, Dodoo D, AdjeiGO,Troye-Blomberg M, Akanmori BD and Adjimani JP (2008). Levels of Soluble CD163 and Severity of Malaria in Children in Ghana. Clinvacc. Immunol. 15: 1456-60. Epub 2008 Jul 16.

 

Books& book chapters

“Towards a blood stage malaria vaccine; dealing with allelic polymorphism in the vaccine candidate apical membrane antigen 1”, PhD thesis (2012).

 University of Ghana Reader series

Gyan B. A, Quaye I.K.E., Kusi, K.A. and Golightly, L. In Search of Novel Markers Involved in the Pathogenesis of Severe Malaria. Book Chapter In, Towards Effective Disease Control in Ghana: Research and Policy Implications 2014, vol 1: Page 48 - 56; Editors, K. A.  Koram, Ahorlu CS, Wilson MD, Bosompem KM

 Kusi. K. A., Amoah, L. E. and Dodoo, D. Immunological Evaluation of Malarial Antigens as Potential Candidate Vaccines. Book Chapter In, Towards Effective Disease Control in Ghana: Research and Policy Implications 2014, vol 1: Page 57 - 65; Editors, K. A.  Koram, Ahorlu CS, Wilson MD, Bosompem KM

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P.O. Box LG 581
Legon, Accra

+233 030 2501178/79

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