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Title

Associate Professor

Name:

Ben Adu Gyan

Academic Qualification

PhD (Immunology), MSc (Immunology), BSc (Hons)

Professional Qualification

Immunology

Email address:

bgyan@noguchi.ug.edu.gh

Telephone:

+233-302-501178/9

Fax number:

+233-302-502128/513202

School/Institute

Noguchi Memorial Institute for Medical Research

Department:

Immunology

Short BIOS/CV

PersonalStatement

My goal is to contribute through research, teaching and mentoring in advancing knowledge and understanding in immunology and pathogenesis of diseases that would be harnessed towards better and quality of people.

 Education

Ph.D (Immunology). Stockholm University, Stockholm, Sweden 2002

MSc., Parasite Immunology, Karolinska Institute, Stockholm, Sweden, 1994 B.Sc. (Hons), Zoology, University of Ghana, Legon, 1984

 Professional Experience

2013-present:              Associate Professor and Head, Immunology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon

 

2006-present: Co-odinator, Students Placement and Research, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon

 

2003-2013:  Senior Research Fellow, Immunology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon

 

1996-2003: Research Fellow; Immunology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon

                       

2001-2002:  Research and Teaching Assistant in Immunological Methods, Department of Immunology Stockholm University, Sweden.

                       

1986:   Principal Research Assistant, Immunology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon             

1987-1996:  Senior Research Assistant, Immunology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon

 

Administrative Role

Head of Department of Immunology

Coordinator for Students Placement

 

Research interest

The key focus of my research over the years is the search for markers or molecules and their mechanisms in the pathogenesis of malaria and other diseases. Thus in the area of basic immunology research, I have  demonstrated record of successful and productive research projects in an area of high relevance in investigating molecules that are possibly involved in the pathogenesis of severe malaria.  I demonstrated for the first time that monocytes are important phenotype of cells that elicit nitric oxide in the killing or inhibition of growth of Plasmodium falciparum (Gyan et al Parasite Immunology. 1994). This finding provided valuable insight into the role of non-antibody mediation during immune response to malaria. Further to this I have carried out studies on the role of haptoglobin(Gyan et al ActaTropica, 2002), an acute phase protein, CD 163 (Kusi et al. Vaccine Immun. 2008) and endothelial progenitor cells(Gyan et al. Am J Trop Med Hyg. 2009) and their interaction or modulation of immune factors during an infection such as malaria.

 In addition I am involved as investigator in malaria vaccine trials. I was a co-investigator in the Phase Ib trial of the EBA-175 RII-NG vaccine in Ghana. Currently, I serve as a investigator/expert of a team of scientists investigatingimmune correlates of protection against malaria after vaccination with RTS,S/AS01E in the ongoing comprehensive Phase III double-blind, randomized, controlled multi-center trial.In recent years extended my research activities to other diseases including schistosomiasis, tuberculosis, diabetes, leishmaniasis and sickle cell disease

 I have a strong passion in train next generation of scientists in Africa through support in graduate students thesis work. I am currently involved in the  development of internship programs in global health for international students

 

Research Projects completed (within the past 5 years):

Phase 1, Double-Blinded, Placebo-Controlled Dosage-Escalation Study of the Safety and Immunogenicity of EBA-175 RII-NG Malaria Vaccine Administered Intramuscularly in Semi-immune Adults.The goal of this study was to assess the safety and reactogenicity (tolerability) of ascending dosages of EBA-175 RII-NG vaccine among healthy semi immune adult subjects given in 3 doses at 0, 1 and 6 months by IM injection.

Role: Co-Investigator

                                          

Multiplexed Detection of food and waterborne pathogens

The aim of the study was to identify multiple food and water-borne bacteria, protozoa and viruses simultaneously from a single sample.

Role: Collaborator

 Immunological Correlates of Protection against Clinical Malaria in a Cohort of young children in the KassenaNankana District of Ghana

Role: Co-investigator

 Study immune correlates of protection against malaria after vaccination with RTS,S/AS01E: of a comprehensive immunological arm of a Phase III double-blind, randomized, controlled multi-center trial

The goal of this study was to investigate mechanisms of vaccine-induced protection against malaria Identify a correlate of vaccine-induced protection

Role: Co-Principal Investigator

 

On-going research projects

NIH Funded 1R01AI074622-01A2       2011-2016

Endothelial progenitor cells and the pathogenesis of cerebral malaria           

The aim of this proposal is to further define the host response to microvascular damage in malaria and determine its association with the development of or recovery from cerebral malaria.

Role: Co-Principal Investigator

 NIH Funded 1 R01AI095789-01A1     2012-2017

Understanding RTS,S malaria vaccine-induced protection through integrated analysis of antibody, B cell and T

cell immune responses

To define the initial protective immune responses targeting CSP upon vaccination with RTS,S/AS01E and to explain duration of protection by defining RTS,S/AS01E modulation of naturally acquired

humoral and cellular immunity to asexual BS parasites.

Role: Co-Investigator

 NIH Funded 1 R01AI099623-01       2012-2017   

Epidemiology and molecular mechanisms of anthelminthic treatment failure in Kintampo North Municipality, Ghana

To define the epidemiology of hookworm infection and specific host factors associated with albendazoletreatment failure in Kintampo, Ghana and to establish methods to detect vitro benzimidazole resistanceand corresponding gene polymorphisms for use in sentinel sites throughout Ghana

Role: Co-Investigator

 

List of Publications:

1.        Isaac Anim-Baidoo, Charles AkugbeyNarh, Dora Oddei, Charles Addoquaye Brown, ChristabelEnweronu-Laryea, Ferdinand Ayeh-Kumi, Ben AduGyan Betty Bandoh, Eric Sampane-Donkor, George Armah, Andrew Anthony Adjei, David Nana Adjei, Patrick. Giardia lamblia infections in children in Ghana Pan African Medical Journal 2016 24, 217,

2.      Yeboah K, Puplampu P, Yorke E, Antwi DA, Gyan B, Amoah AG. Body composition and ankle-brachial index in Ghanaians with asymptomatic peripheral arterial disease in a tertiary hospital. BMC Obes. 2016; 13;3:27.

 

3.      Daniel Amoako-Sakyi, SelormeAdukpo, Kwadwo A. Kusi, Daniel Dodoo, Michael F. Ofori, George O. Adjei, Dominic E. Edoh, Richard H. Asmah, Charles Brown, Bright Adu, DorcasObiri-Yeboah, Godfred Futagbi, Sharif BuariAbubakari, MaritaTroye-Blomberg, Bartholomew D. Akanmori, Bamenla Q. Goka, John Arko-Mensah, Ben A. Gyan. A STAT6 Intronic Single-Nucleotide Polymorphism is Associated with Clinical Malaria in Ghanaian Children. Genet Epigenet. 2016; 8: 7–14

 

4.      Kwame Yeboah, Peter Puplampu, Joana Ainuson, Josephine Akpalu,Ben Gyan, Albert G. B. AmoahPeripheral artery disease and exertional leg symptoms in diabetes patients in Ghana BMC CardiovascDisord. 2016; 16: 68.

 

5.      Richard H. Asmah, Brodrick Y. Amoah, Selorme Adukpo, Charles A. Brown, Henry Asare-Anane, Michael F. Ofori, David N. Adjei, Ben Gyan, Edwin K. Wiredu, Patrick F. Ayeh-Kumi. Uncomplicated malaria infection in pediatric patients in Ghana: relationship with superoxide dismutase. OxidAntioxid Med Sci. 2015; 4(3): 133-137

 

6.      HariniGaneshan, Kwadwo A. Kusi, Dorothy Anum, Michael R. Hollingdale, Bjoern Peters, Yohan Kim, John K. A. Tetteh, Michael F. Ofori, B. A.Gyan, Kwadwo A. Koram, Jun Huang, Maria Belmonte, Jo Glenna Banania, Daniel Dodoo, Eileen Villasante, Martha Sedegah. Measurement of ex vivo ELISpot interferon-gamma recall responses to Plasmodium falciparum AMA1 and CSP in Ghanaian adults with natural exposure to malaria. Malar J. 2016; 15: 55

 

7.      MariamaCherif, D. Amoako-Sakyi, AmaganaDolo, Jan-Olov Pearson, B. Gyan, DorcasObiri-Yeboah, IssaNebie, SodiomonB. Sirima, OgobaraDoumbo, MaritaTroye-Blomberg, MaigaBakary. Distribution of FcγR gene polymorphisms among two sympatric populations in Mali: differing allele frequencies, associations with malariometric indices and implications for genetic susceptibility to malaria. Malar J. 2016; 15: 29.

 

8.      Carmen M. Dickinson-Copeland, Nana O. Wilson, Mingli Liu, Adel Driss, HassanaSalifu, Andrew A. Adjei, Michael Wilson, Ben Gyan, Daniel Oduro, Kingsley Badu, Felix Botchway, Winston Anderson, Vincent Bond, MethodeBacanamwo, Shailesh Singh, Jonathan K. Stiles. Heme-Mediated Induction of CXCL10 and Depletion of CD34+ Progenitor Cells Is Toll-Like Receptor 4 Dependent PLoS One. 2015; 10(11)

 

9.      Arnold D. Forkuo, Charles Ansah, Kwesi M. Boadu, Johnson N. Boampong, Elvis O. Ameyaw, Ben A. Gyan, Andrea T. Arku, Michael F. Ofori. Synergistic anti-malarial action of cryptolepine and artemisinins. Malar J. 2016; 15: 171.

 

10.  C Antwi-Boasiako, E Frimpong, G K Ababio, B Dzudzor, I Ekem, B. Gyan, NA Sodzi-Tettey, D A Antwi. SickleCell Disease: Reappraisal of the Role of Foetal Haemoglobin Levels in the Frequency of Vaso-Occlusive Crisis .Ghana Med J. 2015; 49(2): 102–106

 

11.  Kingsley Badu, Ben Gyan, Maxwell Appawu, Daniel Mensah, Daniel Dodoo, Guiyun Yan, Chris Drakeley, Guofa Zhou, Ellis Owusu-Dabo, KwadwoAnsahKoram. Serological evidence of vector and parasite exposure in Southern Ghana: the dynamics of malaria transmission intensity Parasit Vectors. 2015; 8: 251.

 

12.  George AwukuAsare, Daniel Afriyie, Robert A. Ngala, Alfred A. Appiah, Yvonne Anang, IddiMusah, Samuel Adjei, KwabenaBamfo-Quaicoe, DerickSule, Ben A.Gyan, Peter Arhin, Dominic A. Edoh Shrinkage of Prostate and Improved Quality of Life: Management of BPH Patients with Croton membranaceusEthanolic Root Extract Evid Based Complement Alternat Med. 2015; 2015: 365205

 

13.  Isaac Anim-Baidoo · Charles Narh · DorotheahObiri · ChristabelEwerenonu-Laryea · Eric S Donkor · David N Adjei · Uri S Markakpo · Richard H Asmah · Charles A Brown · George E Armah · Ben A Gyan · Andrew A Adjei · Patrick F Ayeh-Kumi . Cryptosporidial Diarrhoea in Children at a Paediatric Hospital in Accra, Ghana. International Journal of Tropical Disease and Health. 10(3): 1-13, 2015, Article no.IJTDH.18532.

 

14.  Dorothy Anum, Kwadwo A Kusi, HariniGaneshan, Michael R Hollingdale, Michael F Ofori, Kwadwo A Koram, Ben A Gyan, Susan Adu-Amankwah, EdemBadji, Jun Huang, Maria Belmonte, Glenna J Banania, Theophilus B Kwofie, Eileen Villasante, Daniel Dodoo, Martha Sedegah. Measuring naturally acquired ex vivo IFN-γ responses to Plasmodium falciparum cell-traversal protein for ookinetes and sporozoites (CelTOS) in Ghanaian adults. Malar J. 2015; 14: 20.

 

 

15.  Godfred Futagbi, Ben Gyan, Harriet Nunoo, John Tetteh, Jennifer Welbeck, Lorna Renner, Michael Ofori, Daniel Dodoo, Dominic Edoh, Bartholomew Akanmori. High Levels of IL-10 and CD4+CD25hi+. Treg Cells in Endemic Burkitt’s Lymphoma Patients. Biomedicines,2015:  3, 224-236

 

16.  C Antwi-Boasiako E Frimpong G K Ababio D Bartholomew A D Campbell,  B Gyan · D A AntwiIThe Role of Nitric Oxide in Vaso-occlusive Crisis in Sickle Cell Disease Patients in Ghana Donnish Journal of Medicine and Medical Sciences. 2015. 2(4): 52-55

 

17.  Kwame Adu-Bonsaffoh, Daniel AnsongAntwi, Samuel AmenyiObed, Ben GyaN. Nitric oxide dysregulation in the pathogenesis of preeclampsia among Ghanaian women. Integr Blood Press Control. 2015; 8: 1–6

 

18.  Adukpo S, Kusi KA, Ofori MF, Tetteh JK, Amoako-Sakyi D, Goka BQ, Adjei GO, Edoh DA, Akanmori BD, Gyan BA, DodooD.High plasma levels of soluble intercellular adhesion molecule (ICAM)-1 are associated with cerebral malaria.PLoS One. 2013 27;8(12):e84181

 

19.  Asante KP, Owusu-Agyei S, Cairns M, Dodoo D, Boamah EA, Gyasi R, Adjei G, Gyan B, Agyeman-Budu A, Dodoo T, Mahama E, Amoako N, Dosoo DK, Koram K, Greenwood B, Chandramohan D. Placental malaria and the risk of malaria in infants in a high malaria transmission area in Ghana: a prospective cohort study. J Infect Dis. 2013;208(9):1504-13.

 

20.  Paul Tetteh, Charles AntwiBoasiako, Ben Gyan, Daniel Antwi, Festus Adzaku, Kwame Adu-Bonsaffoh,Samuel Obed.  Impaired renal function and increased urinary isoprostane excretion in Ghanaian women with pre-eclampsia. Research and Reports in Tropical Medicine 2013:4 7–13

 

21.  Affum AO, Lowor S, Osae SD, Dickson A, Gyan BA, Tulasi D.A pilot study on quality of artesunate and amodiaquine tablets used in the fishing community of Tema, Ghana. Malar J. 2013 ;12(1):220

 

22.  Afriyie DK, Asare GA, Bugyei K, Asiedu-Gyekye I, Gyan BA, Adjei S, Addo P, Sittie A, Nyarko AK. Anti-atherogenic and anti-ischemic potentials of Croton membranaceus observed during sub-chronic toxicity studies.Pharmacognosy Res. 2013, 5(1):10-6. doi: 10.4103/0974-8490.10564

 

23.  Asuming-Brempong E, Gyan B, Amoah AS, van der Puije W, Bimi L, Boakye D, Ayi I. Relationship between eosinophil cationic protein and infection intensity in a schistosomiasis endemic community in Ghana. Reports in Tropical Medicine. 2015:6 1-10

 

24.  Asare GA, Bugyei K, Fiawoyi I, Asiedu-Gyekye IJ, Gyan B, Adjei S, Addo P, Otu-Nyarko L, Nyarko A. Male rat hormone imbalance, testicular changes and toxicity associated with aqueous leaf extract of an antimalarial plant: Phyllanthusniruri. Pharm Biol. 2013;51(6):691-9.

 

25.  Annan K, Sarpong K, Asare C, Dickson R, Amponsah K, Gyan B, Ofori M, Gbedema S. In vitro anti-plasmodial activity of three herbal remedies for malaria in Ghana: Adeniacissampeloides (Planch.) Harms. Terminaliaivorensis A. Chev, and ElaeisguineensisJacq. Pharmacognosy Res. 2012 4(4):225-9.

 

26.  Aidoo E, Addai FK, Ahenkorah J, Hottor B, Bugyei KA, Gyan BA. Natural cocoa ingestion reduced liver damage in mice infected with Plasmodium berghei (NK65). Research and Reports in Tropical Medicine 2012, 3:107-116.

 

27.  Asare GA, Bugyei K, Sittie A, Yahaya ES, Gyan B, Adjei S, Addo P, Wiredu EK, Adjei DN, Nyarko AK. Genotoxicity, cytotoxicity and toxicological evaluation of whole plant extracts of the medicinal plant Phyllanthusniruri (Phyllanthaceae). Genet Mol Res. 2012 11(1):100-11.

 

28.  Quadt KA, Barfod L, Andersen D, Bruun J, Gyan B,Hassenkam T, Ofori MF, Hviid L. The Density of Knobs on Plasmodium falciparum-Infected Erythrocytes Depends on Developmental Age and Varies among Isolates.PLoS One. 2012;7(9)

 

29.  Berhow MA  Affum AO Gyan BA J Med Food.Rosmarinic acid content in antidiabetic aqueous extract of Ocimumcanumsims grown in Ghana. J Med Food. 2012;15(7):611-20. doi: 10.1089/jmf.2011.0278.

 

30.  S.K. Amponsah,K.A. Bugyei, D. Osei-Safo, F.K. Addai,G. Asare, A. Tsegah, J. Baah,M. Ofori, and Gyan B. . In Vitro Activity of extract and fractions of natural Cocoa powder on Plasmodium falciparum. Journal of Medicinal Foods. 2012;15(5):476-82.

 

31.  Asare GA, Sittie A, Bugyei K, Gyan BA, Adjei S, Addo P, Wiredu EK, Nyarko AK, Otu-Nyarko LS, Adjei DN. Acute toxicity studies of Croton membranaceus root extract. J Ethnopharmacol. 2011;134(3):938-43.

 

32.  Asare GA, Addo P, Bugyei K, Gyan B, Adjei S, Otu-Nyarko LS, Wiredu EK, Nyarko A.

Acute toxicity studies of aqueous leaf extract of Phyllanthusniruri.InterdiscipToxicol. 2011

 4(4):206-10.

 

33.  Adu B, Dodoo D, Adukpo S, Gyan BA, Hedley PL, Goka B, Adjei GO, Larsen SO, Christiansen M, Theisen M. Polymorphisms in the RNASE3 Gene are associated with Susceptibility to Cerebral Malaria in Ghanaian Children.PLoS One. 2011;6(12):e29465

 

34.  Nana Kofi Ayisi, Regina Appiah-Opong, Ben Gyan, KwasiBugyei, and Fred Ekuban. Plasmodium falciparum: Assessment of Selectivity of Action of Chloroquine, Alchorneacordifolia, Ficuspolita, and Other Drugs by a Tetrazolium-Based Colorimetric Assay. Malar Res Treat. 2011;2011:816250

 

35.  Asare GA, Gyan B, Bugyei K, Adjei S, Mahama R, Addo P, Otu-Nyarko L, Wiredu EK, Nyarko A Toxicity potentials of the nutraceuticalMoringaoleifera at supra-supplementation levels. J Ethnopharmacol. 2011 139(1):265-72

 

36.  Michael B. Adinortey, Ben A. Gyan, Jonathan P. Adjimani, Philomena E. Nyarko Charity Sarpong Francis Y. Tsikata Alexander K. NyarkoHaptoglobin Polymorphism and Association with Complications in Ghanaian Type 2 Diabetic Patients. Ind J ClinBiochem 2011; 26(3):261–268

 

37.  Dodoo D, Atuguba F, Bosomprah S, Ansah NA, Ansah P, Lamptey H, Egyir B, Oduro AR, Gyan B, Hodgson A, Koram KA.. Antibody levels to multiple malaria vaccine candidate antigens in relation to clinical malaria episodes in children in the Kasena-Nankana district of Northern Ghana. Malar J. 2011.;10:108

 

38.  Maria Ljungdahl, Christina Montgomerie, B. Gyan, Francis S. Hagbe, Sven Britton. HIV and HCV in a Ghanaian prison ward – A study of prevalence and validation of saliva tests as well as knowledge and stigma. Läkartidningen (Swedish Medical Journal, 2011. Vol 108)

 

39.  Dodoo D, Hollingdale MR, Anum D, Koram KA, Gyan B,Akanmori BD, Ocran J, Adu-Amankwah S, Geneshan H, Abot E, Legano J, Banania G, Sayo R, Brambilla D, Kumar S, Doolan DL, Rogers WO, Epstein J, Richie TL, Sedegah M. Measuring naturally acquired immune responses to candidate malaria vaccine antigens in Ghanaian adults. Malar J., 2011. 20;10:168.

 

40.  Kweku MA, Odoom S, Puplampu N, Desewu K, Nuako GK, Gyan B, Raczniak G, Kronmann KC, Koram K, Botero S, Boakye D, Akuffo H. An outbreak of suspected cutaneous leishmaniasis in Ghana: lessons learnt and preparation for future outbreaks. 2011 Glob Health Action. 4. doi: 10.3402/gha.v4i0.5527

 

41.  Koram KA, Gyan BA.Malaria vaccine development: An endemic country perspective. Hum Vaccin.2010; 24;6(1).

 

42.  Adinortey MB, B.A Gyan, J.P Adjimani, P.E Nyarko, A.K Nyarko. Is there any relationship between haptoglobin phenotypes and retinopathy among Ghanaian diabetics? Journal of the Ghana Science Association 2009. 11: 2, 9-15.

 

43.  Gyan B, Goka BQ, Adjei GO, Tetteh JK, Kusi KA, Aikins A, Dodoo D, Lesser ML, Sison CP, Das S, Howard ME, Milbank E, Fischer K, Rafii S, Jin D, Golightly LM. Cerebral malaria is associated with low levels of circulating endothelial progenitor cells in African children. 2009. Am J Trop Med Hyg. 80(4):541-6.

 

44.  Kusi KA, Gyan BA,Goka BQ, Dodoo D, Obeng-Adjei G, Troye-Blomberg M, Akanmori BD, Adjimani JP.  Levels of soluble CD163 and severity of malaria in children in Ghana. Clin Vaccine.  Immunol.; 2008. 15(9):1456-60.

 

45.  Boraschi D, AbebeAlemayehu M, Aseffa A, Chiodi F, Chisi J, Del Prete G, Doherty TM, Elhassan I, Engers H, Gyan B,Harandi AM, Kariuki T, Kironde F, Kouriba B, Langhorne J, Laskay T, Medaglini D, Olesen O, Onyebujoh P, Palma C, Sauerwein R, Sibanda E, Steinhoff U, Tagliabue A, Thiel A, Vahedi M, Troye-Blomberg M. Immunity against HIV/AIDS, Malaria, and Tuberculosis during Co-Infections with Neglected Infectious Diseases: Recommendations for the European Union Research Priorities. PLoSNegl Trop Dis. 2008: 25;2(6):e255.

 

46.  Rasti N, K I Falk, D Donati, B Gyan, B Q Goka, M Troye-Blomberg, B D Akanmori, J A L Kurtzhals, D Dodoo, R Consolini, A Linde, M Wahlgren, M T Bejarano. Circulating Epstein-Barr Virus in Children living inmalaria endemic areas. Scand J Immunol 2005 61:461-465

 

47.  Gyan Ben, BamenlaGoka, Jasmina T. Cvetkovic, Jorgen L. Kurtzhals, Victoria Adabayeri,HedvigPerlmann, Ann-Kari Lefvert,Bartholomew D.  Akanmori, MaritaTroye-Blomberg .  Allelic polymorphisms in the repeat and promoter regions of the interleukin-4 gene and malaria severity in Ghanaian children. ClinExpImmunol 2004: 138:145-150

 

48.  Minang JT, Gyan BA, Anchang JK, Troye-Blomberg M, Perlmann H, Achidi EA.Haptoglobin phenotypes and malaria infection in pregnant women at delivery in western Cameroon. Acta Trop. 2004;90(1):107-14.

 

49.  Gyan B,Goka B, Cvetkovic JT, Perlmann H, Lefvert AK, Akanmori B, Troye-Blomberg M. Polymorphisms in Interleukin-1beta and Interleukin-1 Receptor Antagonist Genes and Malaria in Ghanaian Children. Scandinavian Journal of Immunology 2002, 56(6):619-622.

 

50.  Gyan BA,Kurtzhals JAL, Akanmori BD, Ofori MF, Goka BQ, Hviid L, Behr C. Elevated levels of nitric oxide and low levels of haptoglobin associated with severe malarial anaemia in African children. ActaTropica, 2002  83:133-140,

 

51.  Goka BQ, Kwarko H, Kurtzhals JAL, Gyan B, Ofori-Adjei E, Ohene SA, Hviid L, Akanmori BD and Neequaye J.  Complement binding to erythrocytes is associated with macrophage activation and reduced haemoglobin in Plasmodium falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 2001:95,545-549

 

52.  Quaye IKE, Ekuban FA, Brandful JAM, Gyan BA,Akanmori BD,Ankrah N-A. Haptoglobin Phenotypes in HIV-1-Seropositive Patients in Ghana: Decreased Risk for Hp0 Individuals.Human Heredity 2000, 50(6):382-283

 

 

53.  Quaye IKE, Ekuban FA, Goka BQ, Adabayeri V, Kurtzhals JAL, Gyan B, Ankrah N-A, Hviid L, Akanmori BD. Haptoglobin 1-1 is associated with susceptibility to severe Plasmodium falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 2000; 94:216-219                     

 

54.  Quaye IKE, Brandful JAM, Ekuban FA, Gyan BA,Ankrah N-A. Haptoglobin polymorphism in human immunodeficiency virus infection: Hp0 phenotype limits depletion of CD4 cell counts in HIV-1-seropositive individuals. Journal of Infectious Diseases.2000:181(4):1483-5.

 

55.  Gyan B A,Afari E, Nkrumah F, Dunyoh S, Perlmann H.  Seroreactivity to Pf 155/RESA in two malaria endemic ecological zones in Southern Ghana. African Journal of Health Sciences 1999, 5(1):42-45.

 

56.  Mensah P, Gyan B,Dodoo D, Osei-Kwasi M, Ayisi NK, Akanmori BD.  Prevalence of Treponemapallidium antibodies in sera of human immunodeficiency virus (HIV) infected and uninfected Ghanaians. GhanaMedical Journal, 1996, 31a: 802-804.

 

57.  Gyan B,Troye-Blomberg M, Perlmann P, Bjorkman. Monocytes cultured with and without interferon-gamma inhibit Plasmodium falciparum parasite growth in vitro via secretion of reactive nitrogen intermediates. Parasite Immunology 1994;16(7):371-5.

 

58.  Quaye IK, Nyame PK, Dodoo D, Gyan B, Adjei AA. Biochemical and haematological markers of alcohol intake in Ghanaians. West African Journal of Medicine. 1992;11(3):199-202

 

59.  Quaye IK, Nyame PK, Dodoo D, Gyan B, Adjei AA. Assessment of anthropometric measurements, blood analytes and liver enzymes in Ghanaian alcoholics. West African Journal of Medicine 1992; 11(4):268-73.

 

60.  Akanmori, BD, Adjei AA, Nyarko AK, Ankra-Badu G, Gyan B, Yamamoto S.  Serum immunoglobulin and complement levels in Ghanaian sickle cell patients in the steady asymptomatic state. East African Medical Journal. 1991  68(5), 378-382

 

61.  Quaye IKE, Nyame PK, Nyarko AK, Akanmori BD, Adjei A, Gyan B, Nutritional status and levels of liver enzymes in Ghanaian alcoholics. Ghana Medical Journal 1990 24: 62-68

 

62.  Akanmori, BD, Afari, EA, Nakano T, Ofori-Adjei D, Owusu-Adjei S, Gyan B, Adjei AA.  In vitro response of Plasmodium falciparum to chloroquine, amaodiaquine, quinine and sulfadoxine/pyrimethamine in Ghana. Ghana Medical Journal. 1989 23, 230-

 

63.  Afari EA., Akanmori BD., Nakano T, Ofori-Adjei D, Gyan B.,Owusu-Adjei S, Adjei A. In vitro and In vivo sensitivity status of P. falciparum to chloroquine in three communities in Ghana. Ghana Medical Journal 1989, 23(4), 227-232

 

 

 

 

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