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Name: Dr. Samuel Adjei
Email address: sadjei@noguchi.ug.edu.gh
Telephone: +233-302-501178/9 ext 3401
Department: Animal Experimentation
Biography

Dr. Samuel Adjei earned BSc. (Hons) in Biological Sciences in 1992 from the Kwame Nkrumah University of Science and Technology (KNUST). In 2002, he proceeded to undertake further studies in Nagoya University, Japan where he obtained MSc. and PhD degrees in Applied Molecular Bioscience (Animal Genetics) in 2004 and 2007, respectively.

In 2008 he became a Research Fellow in the Department of Animal Experimentation. Prior to this, he worked, since October 1995, as a Research Assistant and assisted in the establishment of a standardized Laboratory Animal facility, production and supply of well-defined laboratory animals for biomedical research and the development of the grasscutter as a model animal for buruli ulcer research. He has taught Biology at the Advanced and Senior High School Levels for several years and is also a Part-time lecturer in Principles of Genetics (Level 300) and Advanced Genetics (Level 400) in the Department of Animal Biology and Conservation Science. His specialty training encompasses Laboratory Animal Science, Avian influenza molecular diagnostics, and Medical and Experimental Mammalian Genetics.

Administrative Role:

Head of Department

Research Interests:
  1. Laboratory Animal Science and Technology, Development and establishment of well-defined animals for biomedical research
  2. Phytotherapy and drug development; In vivo evaluation/characterization of some tropical medicinal plant
  3. Medical and experimental mammalian genetics with special interest in uterine leiomyoma (Fibroids) and benign prostate hyperplasia (BPH) studies.
Projects:

Pharmacological effects of Synedrella nodiflora in experimental models of diabetic neuropathy

Anti-epileptic effect and other neuropharmacological effects of the hydro-ethanolic extract of Ehretia cymosa in mice

Genetic polymorphism of SRD5A2 and CYP17 genes in Ghanaian subjects with benign prostatic hyperplasia

Anticonvulsant activity-guided fractionation of Synedrella nodiflora whole plant extract.

Investigation into anti-asthmatic potential of regular consumption of natural cocoa powder in ovalbumin or IgE sensitized guinea-pigs.

Screening Ghanaian medicinal plants for antipsychosis properties.

Observational study: the effect of the aqueous root extract of Croton membranaceus on the treatment of Benign Prostate Hyperplasia and Prostate Cancer.

Intra-ACP Academic mobility scheme project title Enhancing community of practice in one health for infectious diseases through postgraduate training.

Pharmacological study of the antinociceptive effect of Synedrella nodiplora in neuropathic pain.

Developing an alternate anti-epileptic product from medicinal plants: exemplifying utilization of natural resources for quality health.

National Research Network Biomed (NRN Biomed) One Health Ghana Consortium. ACP-EU Grant for enhanced research into infectious diseases.

Effect of some tropical medicinal plants on benign prostate hyperplasia and uterine leiomyoma.

Publications:

Patrick Amoateng, Samuel Adjei, Dorcas Osei-safo, Kennedy K. E. Kukuia, Emelia Oppong Bekoe, Thomas K. Karikari, and Samuel B. Kombian. Extract of Synedrella nodiflora (L) Gaertn exhibits antipsychotic properties in murine models of psychosis. BMC Complementary and Alternative Medicine 17:389 DOI 10.1186/s12906-017-1901-2 (2017)

Patrick Amoateng, Samuel Adjei, Dorcas Osei-Safo, Kennedy K.E. Kukuia, Thomas K. Karikari and Alexander K. Nyarko. An ethanolic extract of Desmodium adscendens exhibits antipsychotic-like activity in mice. J Basic Clin Physiol Pharmacol; DOI 10.1515/jbcpp-2016-0115 (2017)

Patrick Amoateng, Samuel Adjei, Dorcas OseiSafo, Kennedy Kwami Edem Kukuia, Irene Akwo Kretchy, Joseph Adusei Sarkodie, Benoit Banga N’Guessan. Analgesic effects of a hydroethanolic whole plant extract of Synedrella nodiflora (L.) Gaertn in paclitaxelinduced neuropathic pain

in rats. BMC Res Notes 10:226 DOI 10.1186/s13104-017-255 1-7 (2017)

George Awuku Asare, Robert A. Ngala, Daniel Afriyie, Samuel Adjei, Adriana Nyarko, Yvonne Anang-Quartey, Bernice Asiedu, Derek Doku, Brodrick Y. Amoah, Kennedy Bentum, Iddi Musah, Kensese Mossanda. Calcium - Magnesium imbalance implicated in benign prostatic hyperplasia and restoration by a phytotherapeutic drug – Croton membranaceus Müll.Arg. BMC Complementary and Alternative Medicine 17:152 DOI 10.1186/s12906-017-1663-x (2017)

Patrick Amoateng, Samuel Adjei, Dorcas Osei-Safo, Believe Ahedor, Seidu A. Mahmood, Benoit B. N’guessan, Isaac J. Asiedu-Gyekye, Alexander K. Nyarko. Long-term continuous administration of a hydro-ethanolic extract of Synedrella nodiflora (L) Gaertn in male Sprague-Dawley rats: biochemical, haematological and histopathological changes. Ghana Med. J.; 50(3): 163-171 (2016)

Isaac Julius Asiedu-Gyekye, Mahmood Abdulai Seidu, Banga Benoit Nguessan, Samuel FrimpongManso, Joseph Edusei Sarkodie, Samuel Adjei, Schevadnazy Kutu, Joseph Osei-Little1, Alexander Kwadwo Nyarko and Philip Debrah. A dietary strategy for the management of artemether-lumefantrine-induced cardiovascular and renal toxicity. BMC Complementary and Alternative Medicine 16:348, http://dx.doi.org/10.1155/2016/7387286 (2016)

Philip Debrah, Henry Nettey, Katja Kjeldgaard Miltersen, Patrick Ayeh-Kumi, Birgitte Brock, Joseph Adusei Sarkodie, Irene Akwo-Kretchy, Patrick Owusu-Danso, Samuel Adjei, Eskild Petersen and Tore Forsingdal Hardlei. Artemether–Lumefantrine Concentrations in Tablets and Powders from Ghana Measured by a New High-Performance Liquid Chromatography Method. Am J Trop Med Hyg. 95:158-163, (2016)

Isaac Julius Asiedu-Gyekye,1 Kennedy Kwami Edem Kukuia, AbdulaiMahmood Seidu, Charles Antwi-Boasiako, Benoit Banga N’guessan, Samuel Frimpong-Manso, Samuel Adjei, Jonathan Zobi,

Abraham Terkpertey Tettey,1 and Alexander Kwadwo Nyarko. Unsweetened Natural Cocoa Powder Has the Potential to Attenuate High Dose Artemether-Lumefantrine-Induced Hepatotoxicity in Non-Malarious Guinea Pigs. Evidence-Based Complementary and Alternative Medicine Volume 2016, Article ID 7387286, 11 pages http://dx.doi.org/10.1155/2016/7387286 (2016)

George Awuku Asare, Samuel Adjei, Daniel Afriyie, AKua Bempomaa, Appiah-Danquah, Jonas Asia, Bernice Asiedu, Sheila Santa and Derek Doku. Croton membranaceus Improves Some Biomarkers of Cardiovascular Disease and Diabetes in Genetic Animal Models. Journal of Clinical and Diagnostic Research, 9 (12), OF1 ~ OF5, 2015

G. A. Asare, E. S. Yahaya, D. K. Afriyie, S. Adjei and B. Asiedu. Genotoxic and Cytotoxic Activity of Aqueous Extracts of Croton membranaceus in Rodent Bone Marrow and Human Benign Prostate Hyperplasic Cells European Journal of Medicinal Plants 9(2): XX-XX, 2015

Asare GA, Afriyie D, Ngala RA, Annan Y, Appiah AA, Musah X, Adjei S, Bamfo KB, Sule SD, Gyan BA, Edoh DA. Shrinkage of Prostate and Improved Quality of Life: Management of BPH Patients with Croton membranaceus Ethanolic Root Extract. Evidence-based Complementary and Alternative Medicine 02/2015; DOI: 10.1155/2015/365205

Patrick Amoateng, Samuel Adjei , Dorcas Osei-Safo , Elvis Ofori Ameyaw , Believe Ahedor , Benoit Banga N’guessan and Alexander Kwadwo Nyarko. A hydro-ethanolic extract of Synedrella nodiflora (L.) Gaertn ameliorates hyperalgesia and allodynia in vincristine-induced neuropathic pain in rats. J Basic Clin Physiol Pharmacol 26 (4): 383 ~ 394 (2015)

Daniel K. Afriyie, George A. Asare, K. Bugyei, Samuel Adjei, Jiu-mao Lin a, Jun Peng a, Zhen-feng Hong. Treatment of benign prostatic hyperplasia with Croton membranaceus in an experimental animal model. Journal of Ethnopharmacology 157, 90 ~ 98 (2014)

Awortwe C, Asiedu-Gyekye IJ, Nkansah E, Adjei S. Unsweetened natural cocoa has anti-asthmatic potential Int J Immunopathol Pharmacol, 27 (2), 203 ~ 212 (2014)

Samuel Adjei, Patrick Amoateng, Dorcas Osei-Safo, Clement Sasu, Benoit Banga N’guessan, Phyllis Addo, Isaac Asiedu-Gyekye. Sub-acute toxicity of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L) Gaertn in rats. International Journal of Green Pharmacy 8 (4), 271 ~ 275 (2014)

D. K. Afriyie, G. A. Asare, K. Bugyei, I. J. Asiedu-Gyekye, R. Tackie & S. Adjei. Prostate-specific targeting of the aqueous root extract of Croton membranaceus in experimental animals. Andrologia 46, 753 ~ 760 (2014)

S. Adjei, P. Amoateng, D. Osei-Safo, B. Ahedor, B.B. N’guessan, P. Addo and I.J. Asiedu-Gyekye Biochemical and haematological changes following an acute toxicity study of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L) Gaertn in male Sprague-Dawley rats. Journal of Medical and Biomedical Sciences 3(1): 31 ~ 37 (2014)

Asiedu-Gyekye Isaac Julius, Awortwe Charles, Nyamekye Effah Samuel, Antwi Daniel Ansong, Seidu Mahmood, Adjei Samuel, Banga N’guessan Benoit Kwame, Amoateng Patrick, Nkansah Edwin. Nutraceutical with Anti-Inflammatory Activity for the Management of Airway Remodeling in Bronchial Asthma: Kalanchoe integra Var. Crenata (Andr.) Cuf Leaf Extract. Pharmacology & Pharmacy, 5, 250 ~ 261 (2014)

Asiedu-Gyekye Isaac Julius, Awortwe Charles, Tagoe Nii Aryee Benjamin, Antwi Daniel Ansong, Adjei Samuel, Edusei Dwamena Isaac, Benoit N’guessan Banga Kwame, Amoateng Patrick and Nkansah Edwin. Preliminary Investigation of the Anti-asthmatic Potential of Kalanchoe integra Leaf Extract Using a Model of Allergic Airway Inflammation. European Journal of Medicinal Plants 4(5): 542 ~ 562 (2014)

A. A. Appiah, W. A. Asomaning, I. V. Oppong, G. Duker-Eshun, J. Clement, L. K. N. Okine, G. Achel, O. Gyampo, S. Adjei, A. K. Nyarko, F. A. Aboagye, D. A. Edoh, Prospects of Croton membranaceus for Prostate Health. In: African Natural Plant Products Volume II: Discoveries and Challenges in Chemistry, Health, and Nutrition Chapter 6, pp 79 ~ 92. H. Rodolfo Juliani, James E. Simon, Chi-Tang Ho (eds). Copyright © 2013 American Chemical Society.

Antwi Daniel A., Asiedu-Gyekye Isaac J., Awortwe Charles, Adjei Samuel, Addo Phyllis,

A Single Oral High Dose Toxicity Study of Kalanchoe Integra var. crenata (Andr.) Cuf Leaf Extract In ICR Mice: Histopathological and Biochemical changes. Int. J. Med. and Pharm. Sc. 3 (9): 8 ~ 17 (2013)

George Awuku Asare, Kwasi Bugyei, Irene Fiawonu, Isaac Julius Asiedu-Gyekye, Ben Gyan, Samuel Adjei, Phyllis Addo, Lydia Otu-Nyarko, Alexander Nyarko. Male rat hormone imbalance, testicular changes and toxicity associated with aqueous leaf extract of an antimalarial plant: Phyllanthus niruri. Pharm. Biol. 51 (6): 691 ~ 699 (2013)

Afriyie DK, Asare GA, Bugyei K, Asiedu-Gyekye I, Gyan BA, Adjei S, Addo P, Sittie A, Nyarko AK. Anti-atherogenic and anti-ischemic potentials of Croton membranaceus observed during sub-chronic toxicity studies. Pharmacog Res 5 (1): 10~ 16 (2013)

George Awuku Asare, Ben Gyan, Kwasi Bugyei, Samuel Adjei, Razak Mahamaa, Phyllis Addob, Lydia Otu-Nyarkoa, Edwin Kwame Wiredua, Alexander Nyarko. Toxicity potentials of the nutraceutical Moringa oleifera at supra-supplementation levels. Journal of Ethnopharmacology 139: 265 ~ 272 (2012)

G.A. Asare, K. Bugyei, A. Sittie, E.S. Yahaya, B. Gyan, S. Adjei, P. Addo, E.K. Wiredu, D.N. Adjei and A.K. Nyarko. Genotoxicity, cytotoxicity and toxicological evaluation of whole plant extracts of the medicinal plant Phyllanthus niruri (Phyllanthaceae). Genetics and Molecular Research 11 (1): 100 ~ 111 (2012)

George A. Asare, A. Sittie, K. Bugyei, Ben A. Gyan, Samuel Adjei, Phyllis Addo, Edwin K. Wiredu, Alex K. Nyarko, Lydia S. Otu-Nyarko, David Nana Adjei. Acute toxicity studies of Croton membraneous root extract. Journal of Ethnopharmacology 134 (3): 938 ~ 943 (2011)

George Awuku ASARE, Phyllis ADDO, Kwasi BUGYEI, Ben GYAN, Samuel ADJEI, Lydia Serwaa OTU-NYARKO, Edwin Kwame WIREDU, Alexander NYARKO. Acute toxicity studies of aqueous leaf extract of Phyllanthus niruri. Interdiscip. Toxicol. 4(4): 206 ~ 210 (2011)

Samuel Adjei, Akira Sato, Takahiro Nagase, Kazumi Matsubara, Yoichi Matsuda, Takao Namikawa and Akira Ishikawa. A genetic linkage map of the house musk shrew, Suncus murinus, constructed with PCR-based and RFLP markers. Experimental Animals 57: 129 ~ 134 (2008).

Samuel Adjei and Akira Ishikawa. A novel set of microsatellite loci linkage-mapped in the house musk shrew, Suncus murinus. Experimental Animals 56: 51 ~ 56 (2007).

Samuel Adjei, Akira Sato, Shigekazu Tanaka, Eiji Kobayashi, Kazuaki Tanaka,Takao Namikawa and Akira Ishikawa. Development and characterization of CATS markers for genetic linkage mapping in the house musk shrew, Suncus murinus. Experimental Animals 54: 173 ~ 180 (2005)

Phyllis Addo, Alfred Dodoo, Samuel Adjei and Bawa Awumbilla. Optimal duration of male-female expposure to optimise conception in the grasscutter (Thryonomys swinderianus). Livestock Research for Rural Development 15, January, 2003. Online publication available at http://www.cipav.org.co/lrrd.

Phyllis Addo, Alfred Dodoo, Samuel Adjei and Bawa Awumbilla. Determination of the ovulatory mechanism of the grasscuter (Thryonomys swinderianus). Animal Reproductive Science 71, 125 ~ 137 (2002).

 

 

 

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