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Professor  William Ampofo, PhD

Department: Virology

Email: wampofo@noguchi.mimcom.org

Phone: +233 302-501178/9

 Short Bios/CV

Dr. William Ampofo is a Senior Research Fellow, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana. He has a Bachelor’s degree from University of Ghana Legon, and a PhD. from the Tokyo Medical and Dental University, Tokyo, Japan.

Research Interests:

His research interests include molecular and serological investigations of viruses, prevention of viral infections, anti-viral therapy and viral disease.

 Career milestones include the laboratory discovery of the first Ghanaian case of HIV in 1986, first isolation of wild type poliovirus in Ghana, confirmation of first cases in 2007 of highly pathogenic avian influenza H5N1 virus in Ghanaian poultry and establishment of the National Influenza Centre in Ghana 2007. Recently, he supervised the laboratory detection (December 2011) of the first ever cases of Lassa fever virus infection in humans and rodents in Ghana.

 Dr Ampofo also has teaching responsibilities in the University of Ghana, overseeing both undergraduate and postgraduate research. His publications cover medicine, immunology, microbiology, biological sciences and molecular biology. He has a keen interest in the area of maternal and child health and has collaborated in studies on HIV, Hepatitis B and Influenza. He is a recipient of a Commonwealth Scholarship Commission Fellowship as a Visiting Scientist at World Health Organization Collaborating Centre for Influenza, National Institute for Medical Research, U.K.

 In recognition of his significant contribution towards the establishment of surveillance for influenza in Ghana, Dr Ampofo was awarded a United States (US) Department of Defence – Global Emerging Infections Surveillance and Response program Medal of Achievement.  He is a key member of Institutional (ie Biosafety) and national committees (such as HIV Drug Resistance, Laboratory Quality and Pandemic Influenza). Dr. Ampofo has participated in several pandemic influenza preparedness and response activities in Ghana. He has served internationally on temporary assignments with the World Health Organization (WHO), Commonwealth Secretariat Health Division, US Department of Defense, German International Development Agency and the US Agency for International Development. 

In 2010, he was appointed a member of the WHO Strategic Advisory Group of Experts Working Group for Influenza vaccines and Immunization. Since October 2011, he is one of three African region representatives serving on the WHO Pandemic Influenza Preparedness Advisory Group. August 2012 also saw his appointment by the WHO Director-General to a new two year membership of the Global Action Plan Advisory Group for Influenza Vaccines. Dr Ampofo is also currently the American Society for Microbiology Ambassador for Ghana.

He is married with three children and this former national cricketer is currently President of the Ghana Cricket Association.

Details of Research Projects  -

 Title:Quality Assurance of HIV testing in Ghana

Role: Co – Investigator

Budget: about $10,000.0

Period: 1998 to 2003

 Title:       Rural outreach on HIV/AIDS and STD awareness:Birim-North District of Ghana.

Role:Project Coordinator

Budget: GH¢120,000.0 (US $80,000.0)

Period:2000 to 2002

 

Title:Prevention of Mother to Child Transmission (PMTCT) of HIV in Ghana.

Role:Project Coordinator

Budget: GH¢675,000.0 (US $450,000.0)

Period:2000 to 2005

 

Title:Ghana Demographic and Health Survey - HIV testing.

Role:Coordinator - HIV testing

Budget: NMIMR GH¢22,500.0 (US $ 15,000.0)

Period:2003

 

Title: Characteristics of Hepatitis B virus in Ghana.

Role:Co-Investigator

Period:2004

Budget: unavailable

 

Title: Assessment of Serological responses to Hepatitis B and Haemophilus Influenza B

Vaccines in infants receiving vitamin A supplementation.

Role:Co-Investigator

Budget: NMIMR GH¢9,600.0 (US $ 6,400.0)

Period:2004 to 2006

 

Title: Randomized Controlled Trial of SAVVY and HIV in Ghana

Role:Co-Principal Investigator

Budget: NMIMR GH¢2,550,000.0 (US$ 1,700,000.0)

Period:2004 to 2006

 

Title: HIV/AIDS laboratory research support

Role:Principal Investigator

Budget: NMIMR GH¢9,197.0     (US $6,131.0)

Period:2004 to 2006

 

Pathogenesis, National Institute of Health Carlos III, Madrid. Funding was provided by USAID and the United Kingdom Department for International Development.

 

Title:HIV Workplace Policy and Prevention Programme: University ofGhana

Role:Resource Person

Period:2005 to 2007

 

Title:Laboratory Study on Archived Samples: Estimating HIV Incidence Rates Among

Pregnant Women in Ghana

Role:Co-Investigator

Budget: NMIMR GH¢9,000.0   (US $6,131.0)

Period:2005 to 2006

 

Title:    HIV and Sexually Transmitted Infections (STIs) - Neisseria gonorrhoea and

Chlamydia trachomatis - Study among Female Sex Workers in Accra and Kumasi

Role:    Co-Investigator

Budget:           NMIMR GH¢60,000.0 (US $39,700.00)

Period: 2005 to 2006 

 

Title:    Development of Reference Guide on Status Disclosure and Partner Notification for

HIV Voluntary Counselling and Testing (Trainers /Counsellors).

Role:    Resource Person / Academic Supervisor

Budget:NMIMR GH¢ 16,500.0     (US $11,000)

Period: 2005 to 2008 

 

Title:    Research to Improve Infant Nutrition and Growth (RIING)

Role:    Co-Investigator

Period:2005 to 2009

 

Title:    HIV Interactive, Training, Education and Development Centre.

Role:    Resource Person

Period:2006 to 2009

 

Title:    Assessment of susceptibility of Hepatitis B virus genotypes to RNA interference-

mediated gene silencing.

Role:    Co-Principal Investigator

Budget: NMIMR    GH¢97,500.0 ($65,000.00)

Period: 2006 to 2008 

 

Title:    Study on the effect of malaria on HIV disease progression in Kumasi, Ghana

Role:    Resource Person

Budget:           NMIMR GH¢58,500.0    ($39,000.00)

Period: since2008

 

Title:    Surveillance for Influenza virus in acute respiratory illness in Ghana.

Role:    Co-Principal Investigator

Budget: NMIMR GH¢1,050,000.0     (US $700,000.00)

Period: since2007 

 

Title:    Isolation and Characterization of Influenza virus in Children in Accra

Role:    Academic supervisor

Budget:           GH¢ 5,000.0(US $3,333.3)

Period: 2007 - 2009 

 

Title:    A study to assess HIV-1 compartmentalization in Th1 versus Th2 lymphocytes in

individuals co-infected with parasitic infections and HIV-1 in Ghana.

Role:    Co-Principal Investigator

Budget:           NMIMR GH¢37,500.0     (US $25,000.0)

Period: 2007 - 2009 

 

Title:    Characterization of Prevailing HIV Recombinant Strains in Ghanaian Patients on Anti-

Retroviral Therapy in Koforidua, Ghana.

Role:    Co-Investigator

Budget:           Unavailable

Period: since 2007

 

Title:    Monitoring of Emergence of HIV Drug Resistance at Antiretroviral Sites in Ghana.

Role:    Co-Principal Investigator

Budget:           NMIMR GH¢300,000.0     (US $200,000.0)

Period: since 2008 

 

Title:    HIV Drug Resistance Threshold Survey.

Role:    Co-Principal Investigator

Budget:           GH¢255,000.0    (US $170,000.0)

Period: since 2008 

 

Title:    Influenza Viruses in Wild Birds in Ghana.

Role:    Co-Principal Investigator

Budget:           GH¢37,500.0     (US $$25,000.0)

Period: 2008 - 2009 

 

Title:    Ecology of avian influenza viruses in Ghana.

Role:    Co-Principal Investigator

Budget:           GH¢54,000.0     (US $$36,000.0)

Period: 2010 - 2011 

 

Title:    Socio-cultural and Bio-Behavioural survey in High/Low HIV prevalent areas in Ghana.

Role:    Co-Principal Investigator

Budget:           GH¢300,000.0     (US $200,000.0)

Period: 2010 - 2011 

 

Title:    The Ghana Men’s Study: Integrated Biological Behavioural Surveillance Surveys with Population Size Estimation among Men who have Sex with Men.

Role:    Co-Principal Investigator

Budget:           NMIMR GH¢ 299,635.5     (US $199,757.0)

Period: 2010 - 2012

 

Title:    Mapping, Size Estimation, Behavioral and Biological Survey of Female Sex Workers

(FSWs) and Behavioural Survey of their Clients in Ghana.

Role:    Co-Principal Investigator

Budget:           NMIMR GH¢316,971.3     (US $211,314.0)

Period: 2010 - 2011

 

Title:    A population based project to determine the epidemiology and burden of pandemic and

seasonal influenza and risk factors for severe illness in a rural population in Ghana

Role:    Co-Principal Investigator

Budget:           NMIMR GH¢146,055.0     (US $97,370.0)

Period: 2011 - 2012

 

Title:    Epidemiology, Prevention and Treatment of Influenza and Other Respiratory Infections in Ghana in

Role:    Principal Investigator

Budget:           NMIMR GH¢9.0M     (US $4.5M)

Period: 2012 to 2017

 

Publications

1.      Maina EK, Bonney EY, Bukusi EA, Sedegah M, Lartey M, Ampofo WK. CD4+ T cell counts in initiation of antiretroviral therapy in HIV infected asymptomatic individuals; controversies and inconsistencies. Immunology Letters. 2015 Oct 22. pii: S0165-2478(15)30046-8.

2.      Prince Godfred Agbenohevi, John Kofi Odoom, Samuel Bel-Nono, Edward Owusu Nyarko, Mahama Alhassan,David Rodgers, Fenteng Danso, Richard D Suu-Ire, Joseph Humphrey Kofi Bonney, James Aboagye,Karl C Kronmann, Chris Duplessis, Buhari Anthony Oyofo and William Kwabena Ampofo. Biosecurity measures to reduce influenza infections in military barracks in Ghana. BMC Research Notes (2015) 8:14. DOI 10.1186.

3.      Joseph Tuffour, Evelyn Owusu-Mireku, Marie-Therese Ruf, Samuel Aboagye, Grace Kpeli, Victor Akuoku, Janet Pereko, Albert Paintsil, Kofi Bonney, William Ampofo, Gerd Pluschke, and Dorothy Yeboah-Manu. Challenges Associated with Management of Buruli Ulcer/Human Immunodeficiency Virus Coinfection in a Treatment Center in Ghana: A Case Series Study. American Journal of Tropical Medicine and Hygiene, 93(2), 2015, pp. 216–223.

4.      William K. Ampofo, Eduardo Azziz-Baumgartner, Uzma Bashir, Nancy J. Cox, Rodrigo Fasce, Maria Giovanni, Gary Grohmann, Sue Huang, Jackie Katz, Alla Mironenko, Talat Mokhtari-Azad, Pretty Multihartina Sasono, Mahmudur Rahman, Pathom Sawanpanyalert, Marilda Siqueira, Anthony L. Waddell, Lillian Waiboci, John Wood, Wenqing Zhang, Thedi Ziegler, WHO Writing Group1. Strengthening the influenza vaccine virus selection and development process Report of the 3rd WHO Informal Consultation for Improving Influenza Vaccine Virus Selection held at WHO headquarters, Geneva, Switzerland, 1–3 April 2014.

 

5.      Nelson MI, Njouom R, Viboud C, Niang MND, Kadjo H, Ampofo W, Adebayo A, Tarnagda Z, Miller MA, Holmes EC, Diop OM.  Multi-year persistence of two pandemic A/H1N1 influenza virus lineages in West Africa J Infect Dis. 2014; 210 (1): 121-125.

 

6.      Nii-Trebi Nl, Brandful JAM, Ampofo WK, Musah BO, Barnor JS Tokunaga K. Rapid detection of HIV-1 subtypes in Ghana by heteroduplex mobility assay. Int J Biomedical Science and Engineering. 2014; 2: (4), 33-37.

 

7.      Cassels S, Jenness SM, Biney AAE, Ampofo WK, Dodoo FN. Migration, sexual networks, and HIV in Agbogbloshie, Ghana Demographic Research 2014; 31: 861-888.

8.      Jenness SM, Biney AA, Ampofo WK, Nii-Amoo Dodoo F, Cassels S.Minimal coital dilution in Accra, Ghana. Journal of Acquired Immune Deficiency Syndromes. 2015; 69(1):85-91.

9.      Barry O, Powell J, Renner L, Bonney E, Prin M, Ampofo W, Kusah J, Goka B, Sagoe K, Veronika Shabanova V, Elijah Paintsil E.  Effectiveness of first-line antiretroviral therapy and correlates of longitudinal changes in CD4 and viral load among HIV-infected children in Ghana. BMC Infectious Diseases 2013; 13:476  doi:10.1186/1471-2334-13-476

10.  Boru WG, Kikuvi G, Omollo J, Abade A, Amwayi S, Ampofo W, Luman ET, Oundo J. Aetiology and factors associated with bacterial diarrhoeal diseases amongst urban refugee children in Eastleigh, Kenya: A case control study. African Journal of Laboratory Medicine 2013;2 (1) 6 pages. doi: 10.4102/ajlm.v2i1.63

11.  Kronmann KC, Ampofo W, Nzussouo T, Wasfy MO, Agbenohevi P, Carroll J, Diabate M, Sourabie S, Puplampu N, Clemens M, Oyofo BA.  Building military influenza surveillance capacity in West Africa Mil Med. 2013; 178(3):306-14. doi: 10.7205/MILMED-D-12-00273.

12.  Schoub BD, Gessner BD, Ampofo W, Cohen AL, Steffen CA. Afriflu2 Second international workshop on influenza vaccination in the African continent. 8 November 2012, Cape Town (South Africa). Vaccine. 2013, 31(35):3461-6.

  1.  “Yaoundé-like virus in resident wild bird, Ghana.” Williams, Richard A. J., Vázquez, Ana, Asante, Ivy, Bonney, Kofi, Odoom, Shirley,Puplampu, Naiki, Ampofo, William, Sánchez-Seco, María Paz, Tenorio, Antonio and Peterson, A. Townsend. African Journal of Microbiology Research Vol. 6(9), pp. 1966-1969, 9 March, 2012.
  2. Maternal HIV is associated with reduced growth in the first year of life among infants in the Eastern region of Ghana: the Research to Improve Infant Nutrition and Growth (RIING) Project" by Lartey, Anna; Marquis, Grace; Mazur, Robert; Pérez-Escamilla, Rafael; Brakohiapa, Lucy; Ampofo, William; Sellen, Daniel; Adu-Afarwuah, Seth.  Maternal and Child Nutrition. 2012. DOI: 10.1111/j.1740-8709.2012.00441.x

15.  Dzotsi EK, Ohene SA, Asiedu-Bekoe F, Amankwa J, Sarkodie B, Adjabeng M, Ofei A, Oduro J, Atitogbe D, Bonney JHK, Nimo Paintsil SC, Ampofo W.  The first cases of Lassa fever infection in Ghana. Ghana Medical Journal. 2012; 46(3): 166 – 170.

  1. Preterm delivery and low birth weight among neonates born to HIV-positive and HIV-negative Ghanaian women. Laar A. K., Ampofo W., Tuakli J. M., Norgbe G. K. and Quakyi I. A. Journal of Public Health and Epidemiology Vol. 2(9), pp. 224–237, December 2010
  2. Maternal HIV is associated with reduced growth in the first year of life among infants in the Eastern region of Ghana.  Anna Lartey, Grace S Marquis, Rafael Perez-Escamilla, Robert Mazur, Lucy Brakohiapa, William Ampofo and Dan Sellen. FASEB J March 17, 2011 25:216.2
  3. What predicts non-retention in microbicide trials? Feldblum PJ, Halpern V, Lie CC, Obunge O, Ogunsola F, Ampofo W, Opoku K.  ContempClin Trials. 2011 Jul; 32(4):512-6. Epub 2011 Mar 5. 
  4. Improving influenza vaccine virus selection. Ampofo WK, Baylor N, Cobey S, Cox NJ, Daves S, Edwards S, Ferguson N, Grohmann G, Hay A, Katz J, Kullabutr K, Lambert L, Levandowski R, Mishra AC, Monto A, Siqueira M, Tashiro M, Waddell AL, Wairagkar N, Wood J, Zambon M, Zhang W.  Influenza Other Respi Viruses. (2011 Aug 8). doi: 10.1111/j.1750-2659.2011.00277.x. Epub

 

Accepted manuscripts

20.  The first cases of Lassa fever in Ghana. EK Dzotsi, SA Ohene, F Asiedu-Bekoe, J Amankwa, B Sarkodie, M Adjabeng, AM Thouphique, RNA Ofei, J Oduro, D Atitogbe, JHK Bonney, SC NimoPaintsil and W Ampofo. Ghana Medical Journal  GMJ-2012-02-0031.

21.  Virological Surveillance of Influenza-Like Illness among Children in Ghana, 2008-2010. Joseph H.K. Bonney, Karl C. Kronmann, Christina P. Lindan, Ivy A. Asante, Prince Parbie, James Aboagye, Joseph Amankwah, John Kofi Odoom, Michael Adjabeng, NdahwouhTallaNzussouo, Lawson Ahadzie, Robert Vince Barthel, Clair Cornelius, George Amofah, BuhariOyofo, William K. Ampofo.  2012. The Journal of Infectious Diseases MS #49145R1.

 

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+233 030 2501178/79

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