Our Departments
Clinical Pathology Department
The Clinical Pathology Department conducts research that contributes to intervention strategies and safeguards of public health in Ghana. In view of this the Department carries out research into plant medicine development, drug interactions and regulation, bio-monitoring and prevention of poisoning from environmental toxicants (e.g. mycotoxins specifically aflatoxins and toxic heavy metals). The Department also provides specialized laboratory services in support of public health programmes.
Key Research Area of HOD
Toxicology/Pharmacology
Drug development Drug-drug/ herb-drug/ food-drug interactions and drug metabolizing enzymes
- Heavy metal studies
Facilities
Spectrophotometer
High Performance Liquid Chromatography (HPLC) instrument
Freeze dryer
Biosafety Cabinet
Lumex Mercury analyzer
Projects
Mycotoxin studies
i. Evaluation of palatability and acceptance of NovaSil- treated foods Investigators
ii. Modulation of rat liver microsomal protein-mediated aflatoxin biotransformation by Ghanaian vegetables
iii. Determination of fumonisins in weanimix
Drug Development
i. Chemicaland biological fingerprinting of Ghanaian medicinal plants
ii. Studies on Anti-viral and Anti-Parasitic Compounds from Selected Ghanaian Medicinal Plants: Toxicity of medicinal plants
Drug Interactions
- Survey on prevalence of co-use of plant and orthodox medicines in the Ga East District of Ghana.
- Cytochrome P450-mediated drug-drug and herb-drug interaction studies on drugs and herbal preparations used to treat malarial, tuberculosis and HIV
LABORATORY TEST
Laboratory tests conducted by the department include:
MYCOTOXINS
Total aflatoxin measurement (AFB1, AFB2, AG1 and AG2)
Aflatoxin M1 metabolite
Fumonisin (FB1) measurement
HEAVY METALS
Lead, Cadmium, Zinc, Selenium, Arsenic, Mercury, Copper
CLINICAL CHEMISTRY
Liver Function Test
Albumin
Direct bilirubin
Total bilirubin
Total protein
Aspartate aminotransferase (AST)
Alanine aminotransferase (ALT)
Alkaline Phosphatase (ALP)
Gamma-glutamyl transpeptidase (GGT)
Kidney Function Test
Urea
Creatinine
Blood urea nitrogen
Electrolytes (Sodium, Potassium, chloride)
Lipid Profile
Total Cholesterol
High Density Lipoprotein (HDL)
Low Density Lipoprotein (LDL)
Triglycerides
Glucose levels
Fasting blood glucose
Random blood glucose
PHYTOMEDICINE
Evaluation of Safety of herbal products – Acute, Subchronic and Chronic toxicity studies
Efficacy of herbal products – Anticancer and antimalarial activities
STAFF |
|
Senior Research Fellow (Head of Dept.) |
|
Research Fellow |
|
Ms. Abigail Aning | Senior Research Assistant |
Mr. Isaac Tuffour | Senior Research Assistant |
Mr. Kojo Agyeman |
Research Assistant |
Ms. Eunice Dotse |
Research Assistant |
Mr. Justice Kumi | Principal Research Assistant |
Mrs. Eunice E. Ampem Danso |
Laboratory Technologist |
Mr. Ebenezer Ofori-Attah |
Laboratory Technician |
Mr. Francis Attigah
|
Assistant technician |
Ms. Gloria Aku Darko |
Senior Administrative Assistant |