Staff of the Department are highly trained in several biotechnology techniques. Most research activities involve the use of molecular methods such as regular PCR (PCR), quantitative PCR (Q-PCR), genomic sequence and analysis using different software, genetic engineering, probe hybridization techniques, biological and molecular cloning, evaluation of immune markers for laboratory diagnosis of infections, serological assays involving the use of rapid tests, ELISA-based evaluations and immunofluorescent assay techniques. Staff are also deeply involved with cell and tissue culture, as well as virus propagation and isolation. Good laboratory practices are strictly followed and special training provided for staffs who work in a biosafety level 3 (BSL 3) environment with related pathogens. The department also hosts the NATIONAL INFLUENZA CENTRE and the REGIONAL POLIOVIRUS REFERENCE LABORATORY.

Projects list
1) Genetic variability of HIV-1 pol gene in antiretroviral drug-naïve Ghanaian patients.
2) HIV Drug Resistance Monitoring in HIV/AIDS Patients on ART.
3) Establishment of a Cost Effective Micro-Assay for the Early Detection of HIV Transfusion-Associated Infections in Ghana.
4) Characterization of Prevailing HIV Recombinant Strains in Ghanaian Patients on Anti-Retroviral Therapy in Koforidua, Ghana.
5) A study to assess HIV-1 compartmentalization in Th1 versus Th2 lymphocytes in individuals coinfected with parasitic infections and HIV-1 in Ghana

6) Surveillance for Influenza virus in acute respiratory illness in Ghana
7) Nationwide survey of TB/HIV Coinfection in Ghana
8) The effect of malaria on HIV disease progression in Kumasi, Ghana.
9) Correlates of nontransmission of HIV-1 in serologically discordant couples in Accra, Ghana

Collaborators and affiliates of the department include the Ghana AIDS Commission, National AIDS/STI Control Programme of the Ministry of Health, Japan International Cooperation Agency (JICA), Naval Medical Unit -3 of the Department of Defence, USA (NAMRU-3), Centres for Disease Control (CDC), USA, United States Agency for International Development (USAID), and Tokyo Medical and Dental University (TMDU). Also, Department of Microbiology, University of Ghana Medical School (UGMS), Department of Biochemistry, University of Ghana, Koforidua Government hospital, School of Allied Health Sciences, College of Health Sciences, University of Ghana.