Research Fellows

Name: Dr Linda Eva Amoah, PhD, BSc.

Email address: levaamoah@noguchi.ug.edu.gh

Telephone: +233-302-501178

Fax: +233-302-502182

Department: Immunology

Biography

Dr.Amoah joined the NMIMR in 2009 as a Research Fellow. She obtained her PhD from Georgetown University, USA and focused herPhD thesis work on drug resistant malaria.She specialized in the area of de novogene synthesis, heterologous gene expression and purification of recombinant proteins. To further her malaria research capabilities,Dr.Amoah joined the Malaria Research and Reference Reagent Resource Center(MR4) at the ATCC, USAandstill continues to research in malaria. As a visiting scholar, at the University of Copenhagen she helpedproduce a malaria transmission blocking vaccine candidate. Dr.Amoah’s laboratory is taking an integrated approach to both evaluate malaria transmission in the field and the design of new transmission blocking agents. Her laboratory is screening for anti gametocydal drug activity as well as working on identifying parasite and host genetic traits that influence the infectiousness of circulating Plasmodium gametocytes. Dr.Amoah has also organized and facilitated a number of local and international scientific workshops and conferences and is a member of the University of Ghana Malaria Centre of Excellence.

Administrative Role

Research Fellow

Research Interests

  • · Parasite Biology
  • · Vaccine design
  • · Malaria transmission blocking activities
  • · Identification of malaria transmission blocking agents


Projects:

1: 14-POI-GHA/A26804 (Dodoo, PI): 2015 – 2019: DANIDA

Title: Functional immune-genetic correlates of immunity to malaria – The goalsof this project are to identify correlates of immunity to malaria that incorporate aspects of host genetics, parasite genetics and outputs from functional immunological assays.

2: R01AI069314 - 06A1 (Amoah, PI): 2014-2018: US-NIH

Title: Plasmodium falciparum gametocytogenesis – The aim is to better understand the biology and infectiousness of plasmodium falciparum gametocytes

3: URF 6th Call Research Grants (Asamoah, PI) 2013-2015: UG

Title: “Identification of novel HLA class I and II-restricted T cell epitopes of Plasmodium falciparum candidate antigens as potential malaria vaccine components”

4: R03 AI103638-01 (Amoah, PI) 2012 – 2015: US-NIH

Title: Contributions of Pfs48/45 to malaria transmission blocking immunity - The goal is to validate a malaria transmission blocking vaccine candidate and determine natural levels of transmission blocking antibodies in malaria patients

5: UG Malaria Centre for Excellence: 2014 –

The goal of this project is to locally produce a vaccine to combat malariaFunding agency: University of Ghana

GRANT SUPPORT

Funding agency: Aqsens Health Oy 2021 - 2022

Title: Development of a non-invasive malaria diagnostic tool

Role: Principal Investigator

Funding agency: NMCP (Ghana) / Global Fund 2021 - 2022

Title: determining whether histidine rich protein gene deletions causing negative hrp2 RDT results among symptomatic patients with confirmed P. falciparum malaria have reached a threshold for change in diagnostic strategy

Role: Principal Investigator

Funding agency: MERCK 2020 - 2022

Title: Pan African Vivax and Ovale Network (PAVON) - Investigation of the determinants of Plasmodium vivax and Plasmodium ovale infections in Ghana: parasites prevalence and host factors”.

Role: Investigator

Funding agency: Uniformed Services University (USUHS) 2020 - 2022

Title: Strategies to Develop New Field Blood Sample Diagnostics

Role: Investigator

Funding agency: Abbott Diagnostics 2020 - 2022

Title: Evaluation of the health and cost effectiveness of the ultra sensitive NxTEK eliminate malaria RDT kit

Role: Principal Investigator

Funding agency: Jeunes équipes associées à l’IRD 2020 - 2022

Title: STIMULI: The role of the mosquito bite on the dynamics and infectiousness-to-mosquito of asymptomatic Plasmodium falciparum carriers in Ghana

Role: Principal Investigator

Funding agency: Global Fund 2020 - 2021

Title: molecular surveillance of Plasmodium ovale and G6PD deficiency in Ghana

Role: Principal Investigator

Funding agency: National Institute for Health 2019 - 2024

Title: Plasmodium falciparum gametocytogenesis in vitro and in vivo (1R01AI147627-01A1)

Role: Principal Investigator

Funding agency: EDTCP 2019 - 2023

Title: ‘‘Clinical and immunopathological consequences of chronic HBV and Plasmodium falciparum co-infections”.

Role: Co-Investigator

Funding agency: Congressionally Directed Medical Research Program 2019-2022

Title: Novel malaria multi-epitope vaccine design.

Role: Investigator





Publications:

Selected publications

  1. Abuaku B, Amoah LE, Peprah NY, Asamoah A, Amoako EO, Donu D, et al. Malaria parasitaemia and mRDT diagnostic performances among symptomatic individuals in selected health care facilities across Ghana. BMC Public Health. 2021;21(1):239.
  2. Acquah FK, Donu D, Obboh EK, Bredu D, Mawuli B, Amponsah JA, et al. Diagnostic performance of an ultrasensitive HRP2-based malaria rapid diagnostic test kit used in surveys of afebrile people living in Southern Ghana. Malar J. 2021;20(1):125.
  3. Bredu D, Donu D, Amoah LE. Dynamics of the Composition of Plasmodium Species Contained within Asymptomatic Malaria Infections in the Central Region of Ghana. J Trop Med. 2021;2021:7419548.
  4. Kusi KA, Aggor FE, Amoah LE, Anum D, Nartey Y, Amoako-Sakyi D, et al. Identification of Plasmodium falciparum circumsporozoite protein-specific CD8+ T cell epitopes in a malaria exposed population. PLoS One. 2020;15(2):e0228177.
  5. Acquah FK, Lo AC, Akyea-Mensah K, Abagna HB, Faye B, Theisen M, et al. Stage-specific Plasmodium falciparum immune responses in afebrile adults and children living in the Greater Accra Region of Ghana. Malar J. 2020;19(1):64.
  6. Jibira Y, Cudjoe E, Tei-Maya FM, Ayensu B, Amoah LE. The Effectiveness of Varying Combination Ratios of A. cordifolia and M. indica against Field and Laboratory Strains of P. falciparum In Vitro. J Parasitol Res. 2020;2020:8836771.
  7. Frimpong A, Amponsah J, Adjokatseh AS, Agyemang D, Bentum-Ennin L, Ofori EA, et al. Asymptomatic Malaria Infection Is Maintained by a Balanced Pro- and Anti-inflammatory Response. Front Microbiol. 2020;11:559255.
  8. Prajapati SK, Ayanful-Torgby R, Pava Z, Barbeau MC, Acquah FK, Cudjoe E, et al. The transcriptome of circulating sexually committed Plasmodium falciparum ring stage parasites forecasts malaria transmission potential. Nat Commun. 2020;11(1):6159.
  9. Prah DA, Amoah LE, Gibbins MP, Bediako Y, Cunnington AJ, Awandare GA, et al. Comparison of leucocyte profiles between healthy children and those with asymptomatic and symptomatic Plasmodium falciparum infections. Malar J. 2020;19(1):364.
  10. Obboh EK, Okonu RE, Amoah LE. Large Variations in Malaria Parasite Carriage by Afebrile School Children Living in Nearby Communities in the Central Region of Ghana. J Trop Med. 2020;2020:4125109.
  11. Amoah LE, Abuaku B, Bukari AH, Dickson D, Amoako EO, Asumah G, et al. Contribution of P. falciparum parasites with Pfhrp 2 gene deletions to false negative PfHRP 2 based malaria RDT results in Ghana: A nationwide study of symptomatic malaria patients. PLoS One. 2020;15(9):e0238749.
  12. Acquah FK, Donu D, Bredu D, Eyia-Ampah S, Amponsah JA, Quartey J, et al. Asymptomatic carriage of Plasmodium falciparum by individuals with variant blood groups and haemoglobin genotypes in southern Ghana. Malar J. 2020;19(1):217.
  13. Cudjoe E, Donu D, Okonu RE, Amponsah JA, Amoah LE. The In Vitro Antiplasmodial Activities of Aqueous Extracts of Selected Ghanaian Herbal Plants. J Parasitol Res. 2020;2020:5041919.

14.Amoah LE, Acquah FK, Nyarko PB, Cudjoe E, Donu D, Ayanful-Torgby R, et al. Comparative analysis of asexual and sexual stage Plasmodium falciparum development in different red blood cell types. Malar J. 2020;19(1):200.

15.Usui M, Prajapati SK, Ayanful-Torgby R, Acquah FK, Cudjoe E, Kakaney C, et al. Plasmodium falciparum sexual differentiation in malaria patients is associated with host factors and GDV1-dependent genes. Nat Commun. 2019;10(1):2140.

16.Abukari Z, Okonu R, Nyarko SB, Lo AC, Dieng CC, Salifu SP, et al. The Diversity, Multiplicity of Infection and Population Structure of P. falciparum Parasites Circulating in Asymptomatic Carriers Living in High and Low Malaria Transmission Settings of Ghana. Genes (Basel). 2019;10(6).

17.Amoah LE, Abagna HB, Ayanful-Torgby R, Blankson SO, Aryee NA. Diversity and immune responses against Plasmodium falciparum gametocytes in non-febrile school children living in Southern Ghana. Malar J. 2019;18(1):265.

18.Dieng CC, Gonzalez L, Pestana K, Dhikrullahi SB, Amoah LE, Afrane YA, et al. Contrasting Asymptomatic and Drug Resistance Gene Prevalence of Plasmodium falciparum in Ghana: Implications on Seasonal Malaria Chemoprevention. Genes (Basel). 2019;10(7).

19.Amoah LE, Donu D, Abuaku B, Ahorlu CS, Arhinful D, Afari EA, et al. Probing the composition of Plasmodium species contained in malaria infections in the Eastern region of Ghana. BMC Public Health. 2019;19.

20.Acquah FK, Adjah J, Williamson KC, Amoah LE. Transmission-Blocking Vaccines: Old Friends and New Prospects. Infect Immun. 2019;87(6).


Complete list of publications

https://pubmed.ncbi.nlm.nih.gov/?term=amoah%2C+linda&sort=date&size=50



Book Chapters

  • Cheikh Cambel Dieng, Colby T. Ford, Jennifer Huynh, Linda E. Amoah, Yaw A. Afrane, Daniel A. Janies and Eugenia Lo (March 19th 2021). Progress in Parasite Genomics and Its Application to Current Challenges in Malaria Control (Online First), IntechOpen, DOI 10.5772/intechopen.96530

  • Kwadwo Asamoah Kusi, Linda Eva Amoah and Daniel Dodoo. Towards effective disease control in Ghana: research and policy implications: Malaria. 2014 edited by Kwadwo Ansah Koram, Collins K. Ahorlu, Michael D Wilson, Dorothy Yeboah-Manu and Kwabena M. Bosompem


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