National HIV Drug Resistance Genotyping Laboratory

National HIV Drug Resistance Genotyping Laboratory

Virology Department.


1. Professor William Kwabena Ampofo

2. Evelyn Yayra Bonney

Ghana established an Anti-Retroviral Therapy (ART) program in 2003 and has scaled up provision of ART nationwide. However, provision of ART increases the development of HIV drug resistance (HIVDR). The National Expert Committee (NEC) on HIVDR is coordinated by the National AIDS/STI Control Programme of the Ghana Health Service. The NEC has developed a national plan for HIVDR surveillance with systems and protocols to monitor development of resistance and transmission of resistant strains. The NMIMR has been designated the national HIVDR laboratory charged with the responsibility to conduct laboratory investigations to identify HIV resistant strains in Ghana.

Current scope work includes:

HIV serological typing; HIV diagnosis by antibody (serology) and nucleic acids (PCR); HIV viral load;

Immune markers of infection ie CD4 measurements; Genotyping of HIV-1 by RNA extraction, PCR and Sequencing to detect HIV drug resistance mutations

Key achievements (incl. publications):

1. First HIVDR Threshold Survey in Ghana. 2009/2010. Ghana Medical Journal. June 2013. Vol 47, number 2. “Low level of transmitted HIV Drug Resistance at two HIV care centres in Ghana: a threshold survey”.

2. Efficacy of Treatment and Drug Resistance Monitoring in HIV-1-infected Patients on Anti- Retrovirals (ARVs) in Koforidua and Tamale in Ghana. Oral presentation at International Symposium on AIDS and Tuberculosis (ISAT), 13-14th Jan, 2010, Sendai, Japan.

3. Abstract No. CDB113 “Appearance of HIV drug resistance mutations amongst patients on 2nd –line antiretroviral therapy in Ghana” (e-poster), 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention, 17-20th July, 2011 Rome, Italy.

4. Manuscript titled “HIV-1 Drug-Resistance Surveillance among Treatment-Experienced and -Naïve Patients after the Implementation of Antiretroviral Therapy in Ghana” PLoS One 2013.

5. Abstracts below selected for oral presentation in Track B: Epidemiology and Basic science, at the third National HIV and AIDS Research Conference (NHARCON) to be held in Accra, Ghana. Sept 2013.

a. “Serological profiles of HIV infected patients on Antiretroviral therapy in Ghana”

b. “HIV drug resistance mutations in patients on antiretroviral therapy in Ghana”.

6. Study with title “HIV drug resistance profiles in Ghanaian women on antiretrovirals after prevention of mother-to-child transmission” currently underway as a PhD student research programme.

7. Preparations underway to become accredited as member of WHO HIV RESNET by March 2014.

The Noguchi Memorial Institute for Medical Research (NMIMR), set up in 1979 as a semi autonomous institute of the University, is the leading biomedical research facility in Ghana.

© 2021 NMIMR

Get In Touch